Energy-sensing and signaling by AMP-activated protein kinase in skeletal muscle

WW Winder - Journal of applied physiology, 2001 - journals.physiology.org
AMP-activated protein kinase (AMPK) is emerging as an important energy-sensing/signaling
system in skeletal muscle. This kinase is activated allosterically by 5′-AMP and inhibited …

Energy sensing by the AMP-activated protein kinase and its effects on muscle metabolism

DG Hardie - Proceedings of the Nutrition Society, 2011 - cambridge.org
The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status, and a
regulator of energy balance at both the cellular and whole body levels. Although …

AMP-activated protein kinase in skeletal muscle: from structure and localization to its role as a master regulator of cellular metabolism

CA Witczak, CG Sharoff, LJ Goodyear - Cellular and Molecular Life …, 2008 - Springer
The AMP-activated protein kinase (AMPK) is a metabolite sensing serine/threonine kinase
that has been termed the master regulator of cellular energy metabolism due to its numerous …

[PDF][PDF] AMP-activated protein kinase: a key system mediating metabolic responses to exercise

DG Hardie - Medicine & Science in Sports & Exercise, 2004 - paulogentil.com
ABSTRACT HARDIE, DG AMP-Activated Protein Kinase: A Key System Mediating Metabolic
Responses to Exercise. Med. Sci. Sports Exerc., Vol. 36, No. 1, pp. 28–34, 2004. The finding …

Selective suppression of AMP-activated protein kinase in skeletal muscle: update on 'lazy mice'

J Mu, ER Barton, MJ Birnbaum - Biochemical Society …, 2003 - portlandpress.com
AMP-activated protein kinase (AMPK) is becoming recognized as a critical regulator of
energy metabolism in cells. Using a mouse model in which we specifically blocked AMPK …

Intensified exercise training does not alter AMPK signaling in human skeletal muscle

SA Clark, ZP Chen, KT Murphy… - American Journal …, 2004 - journals.physiology.org
The AMP-activated protein kinase (AMPK) cascade has been linked to many of the acute
effects of exercise on skeletal muscle substrate metabolism, as well as to some of the …

[HTML][HTML] Dual regulation of the AMP‐activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle

M Ponticos, QL Lu, JE Morgan, DG Hardie… - The EMBO …, 1998 - embopress.org
The AMP‐activated protein kinase (AMPK) is activated by a fall in the ATP: AMP ratio within
the cell in response to metabolic stresses. Once activated, it phosphorylates and inhibits key …

Role of AMPK in skeletal muscle metabolic regulation and adaptation in relation to exercise

SB Jørgensen, EA Richter… - The Journal of …, 2006 - Wiley Online Library
The 5′‐AMP‐activated protein kinase (AMPK) is a potent regulator of skeletal muscle
metabolism and gene expression. AMPK is activated both in response to in vivo exercise …

Cellular energy sensing and signaling by AMP-activated protein kinase

WW Winder, DM Thomson - Cell biochemistry and biophysics, 2007 - Springer
AMP-activated protein kinase (AMPK) is an energy sensing/signaling protein that, when
activated, increases ATP production by stimulating glucose uptake and fatty acid oxidation …

Exercise-induced AMPK activity in skeletal muscle: role in glucose uptake and insulin sensitivity

M Friedrichsen, B Mortensen, C Pehmøller… - Molecular and cellular …, 2013 - Elsevier
The energy/fuel sensor 5′-AMP-activated protein kinase (AMPK) is viewed as a master
regulator of cellular energy balance due to its many roles in glucose, lipid, and protein …