Targeting DEP domain containing 1 in anaplastic thyroid carcinoma: Implications for stemness regulation and malignant phenotype suppression
C Zhu, S Ke, Y Li, W Zhang, Y Che, R Zhang, P Huang… - Heliyon, 2024 - cell.com
Background Anaplastic thyroid carcinoma (ATC), a rare but highly aggressive endocrine
malignancy, is characterized by a significant presence of cancer stem-like cells (CSCs) …
malignancy, is characterized by a significant presence of cancer stem-like cells (CSCs) …
JAK/STAT3 and NF-κB signaling pathways regulate cancer stem-cell properties in anaplastic thyroid cancer cells
K Shiraiwa, M Matsuse, Y Nakazawa, T Ogi, K Suzuki… - Thyroid, 2019 - liebertpub.com
Background: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and
refractory cancers, and a therapy with a new concept needs to be developed. Recently …
refractory cancers, and a therapy with a new concept needs to be developed. Recently …
Weighted gene co-expression network reveals driver genes contributing to phenotypes of anaplastic thyroid carcinoma and immune checkpoint identification for …
X Dong, Y Yang, J Hou, W Chen, Q Yuan, G Xu… - Frontiers in …, 2022 - frontiersin.org
Background Anaplastic thyroid carcinoma (ATC) is a rare but extremely malignant tumor,
with a rapid growth rate and early metastasis thus leading to poor survival of patients. The …
with a rapid growth rate and early metastasis thus leading to poor survival of patients. The …
Identification of hub genes in anaplastic thyroid carcinoma: evidence from bioinformatics analysis
L Li, M Zhu, H Huang, J Wu… - Technology in cancer …, 2020 - journals.sagepub.com
Anaplastic thyroid carcinoma (ATC) is a rare type of thyroid cancer that results in fatal clinical
outcomes; the pathogenesis of this life-threatening disease has yet to be fully elucidated …
outcomes; the pathogenesis of this life-threatening disease has yet to be fully elucidated …
Expression of cancer stem cell markers is more frequent in anaplastic thyroid carcinoma compared to papillary thyroid carcinoma and is related to adverse clinical …
JY Yun, YA Kim, JY Choe, H Min, KS Lee… - Journal of clinical …, 2014 - jcp.bmj.com
Background Thyroid cancer is one of the most commonly detected cancers worldwide, and
papillary thyroidal carcinoma (PTC) accounts for the majority of thyroid cancers. In contrast …
papillary thyroidal carcinoma (PTC) accounts for the majority of thyroid cancers. In contrast …
Cancer stem-like cell behavior in anaplastic thyroid cancer: A challenging dilemma
Aims Anaplastic thyroid carcinoma (ATC) is an undifferentiated tumor of the thyroid which is
characterized with poor prognosis, leading to its aggressive behavior and resistance to …
characterized with poor prognosis, leading to its aggressive behavior and resistance to …
The bHLH transcription factor DEC1 promotes thyroid cancer aggressiveness by the interplay with NOTCH1
C Gallo, V Fragliasso, B Donati, F Torricelli… - Cell Death & …, 2018 - nature.com
Aberrant re-activation of transcription factors occurs frequently in cancer. Recently, we found
the basic helix-loop-helix transcription factors DEC1 and DEC2 significantly up-regulated in …
the basic helix-loop-helix transcription factors DEC1 and DEC2 significantly up-regulated in …
ISG15 and ISGylation modulates cancer stem cell-like characteristics in promoting tumor growth of anaplastic thyroid carcinoma
T Xu, C Zhu, J Chen, F Song, X Ren, S Wang… - Journal of Experimental …, 2023 - Springer
Background Anaplastic thyroid carcinoma (ATC) was a rare and extremely malignant
endocrine cancer with the distinct hallmark of high proportion of cancer stem cell-like …
endocrine cancer with the distinct hallmark of high proportion of cancer stem cell-like …
Targeting super-enhancer-driven oncogenic transcription by CDK7 inhibition in anaplastic thyroid carcinoma
X Cao, L Dang, X Zheng, Y Lu, Y Lu, R Ji, T Zhang… - Thyroid, 2019 - liebertpub.com
Background: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive
malignancies, with no effective treatment currently available. The molecular mechanisms of …
malignancies, with no effective treatment currently available. The molecular mechanisms of …
Multiple pluripotent stem cell markers in human anaplastic thyroid cancer: the putative upstream role of SOX2
V Carina, G Zito, G Pizzolanti, P Richiusa… - Thyroid, 2013 - liebertpub.com
Background: Anaplastic thyroid carcinoma (ATC) is a rare and aggressive endocrine tumor
with highly undifferentiated morphology. It has been suggested that cancer stem cells …
with highly undifferentiated morphology. It has been suggested that cancer stem cells …
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