Engineering pluripotency through nuclear reprogramming and directing stem cells into
defined lineages underscores cell fate plasticity. Acquisition of and departure from stemness …

The bioenergetics of somatic dedifferentiation into induced pluripotent stem cells remains
largely unknown. Here, stemness factor-mediated nuclear reprogramming reverted …

Nuclear reprogramming with stemness factors enables resetting of somatic differentiated
tissue back to the pluripotent ground state. Recent evidence implicates mitochondrial …

Energy metabolism is traditionally considered a reactive homeostatic system addressing
stage-specific cellular energy needs. There is however growing appreciation of metabolic …

For many years, stem cell metabolism was viewed as a byproduct of cell fate status rather
than an active regulatory mechanism; however, there is now a growing appreciation that …

Highlights•Regulation is highly-dynamic, cell-type specific and involved in cell fate
determination.•Aerobic glycolysis is a feature of 'primed'pluripotent cells and widely seen in …

Reprogramming involves multiple layers of molecular regulation, yet it remains relatively
unknown how the cell's metabolism is changing and/or contributing to this process. In this …

Nuclear reprogramming resets differentiated tissue to generate induced pluripotent stem
(iPS) cells. While genomic attributes underlying reacquisition of the embryonic-like state …

Accumulating evidence implicates mitochondrial and metabolic pathways in the
establishment of pluripotency, as well as in the control of proliferation and differentiation …

Plasticity in energy metabolism allows stem cells to match the divergent demands of self-
renewal and lineage specification. Beyond a role in energetic support, new evidence …