Oligodeoxynucleotides containing CpG dinucleotides in specific sequence contexts activate
the vertebrate immune system. Our previous studies showed that the 5′-end of a CpG …

Synthetic oligodeoxyribonucleotides containing CpG dinucleotides exhibit potent
immunostimulatory activity in vertebrates. Although the molecular mechanisms of …

The genomes of bacterial and viral DNA contain a much higher frequency of unmethylated
CpG dinucleotides than those of vertebrates. This difference in genome structure allows the …

Synthetic oligodeoxyribonucleotides containing CpG-dinucleotides (CpG DNA) in specific
sequence contexts activate the vertebrate immune system. We have examined the effect of …

A series of 21 phosphodiester oligodeoxyribonucleotides containing the core sequence 5 '-
GACGTT-3 'or related control sequences were prepared and tested for their …

The goal of using of oligodeoxyribonucleotides containing CpG dinucleotides (CpG DNA) as
immunomodulatory agents has been realized in recent years. Therapeutic applications of …

The effect of nucleobase deletion in the 3′-or the 5′-flanking sequence to a CpG-motif on
immunostimulatory activity of CpG-containing oligonucleotides was examined by cell …

Abstract Oligodeoxyribonucleotides containing CpG dinucleotides (CpG DNAs) are currently
being evaluated as novel immunomodulators in clinical trials. Recently, we showed that an …

Unmethylated CpG dinucleotides present within certain specific sequence contexts in
bacterial and synthetic DNA stimulate innate immune responses and induce cytokine …

Bacterial DNA and synthetic oligodeoxynucleotides containing unmethylated CpG-motifs in
a particular sequence context activate vertebrate immune cells. We examined the …