OBJECTIVE—The effectiveness of intentional weight loss in reducing cardiovascular
disease (CVD) events in type 2 diabetes is unknown. This report describes 1-year changes …

Overweight and obesity are major contributors to both type 2 diabetes and cardiovascular
disease (CVD). Moreover, individuals with type 2 diabetes who are overweight or obese are …

Abstract The Look AHEAD (Action for Health in Diabetes) study is a multicenter, randomized
controlled trial designed to determine whether intentional weight loss reduces …

Background Lifestyle interventions produce short-term improvements in glycemia and
cardiovascular disease (CVD) risk factors in individuals with type 2 diabetes mellitus, but no …

OBJECTIVE Short-term weight loss improves cardiovascular disease (CVD) risk factors. We
sought to determine the longer-term effects of maintaining weight loss or, conversely …

Background Weight loss is recommended for overweight or obese patients with type 2
diabetes on the basis of short-term studies, but long-term effects on cardiovascular disease …

OBJECTIVE—Diabetes Prevention Program (DPP) participants randomized to the intensive
lifestyle intervention (ILS) had significantly reduced risk of diabetes compared with placebo …

Given the array of adverse health consequences of obesity, including increased risk for type
2 diabetes mellitus (T2DM) and cardiovascular disease (CVD), the Look AHEAD trial (N …

OBJECTIVE To assess the effect of lifestyle intervention over 2 years on changes in weight,
coronary heart disease (CHD) risk factors, and incidence of diabetes in overweight …

OBJECTIVE This study examined specific measures of weight loss in relation to incident
diabetes and improvement in cardiometabolic risk factors. RESEARCH DESIGN AND …