The effects of neurotoxic lesions to the medial prefrontal cortex on both the acquisition and
maintenance of intravenous cocaine self-administration were examined. In one experiment …

The presynaptic mechanisms involved in the initiation of cocaine reinforcement were
investigated using neurotoxin lesions. Rats were trained to intracranially self-administer …

It has been suggested that the initiation and maintenance of cocaine self-administration (SA)
is critically dependent on the dopaminergic (DA) projection to the medial prefrontal cortex …

Four experiments examined the effects of excitotoxic, axon-sparing lesions of the medial
prefrontal cortex or anterior cingulate cortex in rats on responding under different schedules …

Rats were trained to self-administer intravenous cocaine under a progressive ratio (PR)
schedule of reinforcement. Under this schedule, an increasing number of lever responses …

Extracellular levels of dopamine are increased in response to systemic administration of
cocaine in several brain areas including the nucleus accumbens and medial prefrontal …

Neuronal systems involved in the initiation of reinforcement following the response-
contingent delivery of cocaine into the medial prefrontal cortex were investigated. Dose …

It has been postulated that behavioral sensitization to cocaine is associated with an
attenuation of cocaine-induced dopamine (DA) transmission in the medial prefrontal cortex …

The medial prefrontal cortex (mPFC) has been implicated in the development of behavioral
sensitization, which is the progressive enhancement of locomotor activity that occurs with …

Compulsive drug use and a persistent vulnerability to relapse are key features of addiction.
Imaging studies have suggested that these features may result from deficits in prefrontal …