Stem cell factor (SCF) plays important roles in hematopoiesis and the survival, proliferation,
and differentiation of mast cells, melanocytes, and germ cells. SCF mediates its biological …

Stem cell factor (SCF) is an early-acting hematopoietic cytokine that elicits multiple
biological effects. SCF is dimeric and occurs in soluble and membranebound forms. It …

The receptor tyrosine kinase c-Kit and its ligand Stem Cell Factor (SCF) are essential for
haemopoiesis, melanogenesis and fertility. SCF acts at multiple levels of the haemopoietic …

Stem cell factor (SCF) is a cytokine that is active toward hematopoietic progenitor cells and
other cell types, including germ cells, melanocytes, and mast cells, which express its …

Although much is now known about the biological properties of the c-kit receptor and its
ligand, stem cell factor (SCF), little is known of the structural basis for the binding and …

The stem cell factor (SCF) is a polypeptide ligand that is essential for the development of
germ cells, hematopoietic progenitor cells, and melanocyte precursors. It binds to a tyrosine …

The protooncogene c-kit encodes a tyrosine kinase receptor for the stem cell factor (SCF).
Mutants of c-kit were shown to confer a pleiotropic defective phenotype and often display …

Stem cell factor (SCF) is a growth factor that promotes the survival, proliferation, and
differentiation of hematopoietic cells. SCF and its receptor, Kit, are normally present in both …

The binding of the stem cell factor (SCF) to the c-kit-encoded receptor tyrosine kinase
stimulates a variety of biochemical responses that culminate in cellular proliferation …

Stem cell factor (SCF) binds and activates the receptor tyrosine kinase c-Kit, and this
interaction is critical for normal hematopoiesis. SCF also synergizes with a variety of growth …