Irritable bowel syndrome (IBS) is a functional disorder of the gastrointestinal (GI) tract
characterized by pain or discomfort from the lower abdominal region, which is associated …

Recent advances in brain science have shown that the brain function encoding emotion
depends on interoceptive signals such as visceral pain. Visceral pain arose early in our …

Objective The gut is a major site of contact between immune and sensory systems and
evidence suggests that patients with irritable bowel syndrome (IBS) have immune …

Recent research has demonstrated that enteric neural and smooth muscle function is
modulated by the immune system and influenced by mucosal inflammation. In addition …

Irritable bowel syndrome (IBS) is a common functional gastrointestinal (GI) disorder
characterized by visceral hypersensitivity throughout the GI tract [1]. Most studies, however …

Our understanding of the pathophysiology of irritable bowel syndrome (IBS) has evolved
from a disorder of motility to a more integrated understanding of enhanced motility and …

Background & Aims: Irritable bowel syndrome (IBS) is characterized by visceral
hypersensitivity, possibly related to abnormal brain-gut communication. Positron emission …

BACKGROUND AND AIMS: The responsiveness of the central nervous system is altered in
patients with irritable bowel syndrome (IBS). However, because of variations in experimental …

Irritable bowel syndrome is a common disorder defined by a symptom complex including
abdominal pain and altered bowel habit. The etiopathogenesis appears to be multifactorial …

Alterations of visceral sensation such as enhanced perception of physiological or
experimental visceral stimuli along with hypervigilance to those, are at the origin of visceral …