Chronic abdominal pain accompanying intestinal inflammation emerges from the
hyperresponsiveness of neuronal, immune and endocrine signaling pathways within the …

Chronic inflammatory bowel disease (IBD—Crohn's disease [CD] and ulcerative colitis [UC])
are conditions characterized by widespread changes in bowel physiology, including …

Altered central processing, abnormal gastrointestinal motility and visceral hypersensitivity
may be possible major pathophysiology of irritable bowel syndrome (IBS). These factors …

Irritable bowel syndrome (IBS) is a multifactorial disorder characterized by abdominal pain
and altered bowel habits. Chronic symptoms may occur due to changes in gastrointestinal …

Neural control mechanisms play a critical role in pain perception and modulation of
gastrointestinal motility. However, little is known about the role of the nervous system in …

Irritable bowel syndrome (IBS) is a chronic, recurrent disorder that is characterized by
abdominal pain associated with defecation. IBS was previously considered to manifest …

The pathogenesis of irritable bowel syndrome (IBS) is complex, and, although it has evolved
over the years (Fig. 1), it is still not well-understood. A unifying theme is that the symptoms of …

Abstract Background and Aims Despite relevance to pain chronicity, disease burden, and
treatment, mechanisms of pain perception for different types of acute pain remain …

Visceral pain arising from inner organs differs from somatic pain in crucial aspects, limiting
the possibility to transfer knowledge derived from somatic pain research. The …

In this issue, you will find a paper by Keszthelyi et al. entitled 'Alterations in mucosal
neuropeptides in patients with irritable bowel syndrome and ulcerative colitis (UC) in …