Nitric oxide (NO) at high levels is cytotoxic, and may be involved in a range of inflammatory,
neurodegenerative, and cardio-vascular/ischaemic pathologies. The mechanism of NO …

The goal of this study was to explore the occurrence of nitrated proteins in mitochondria
given that these organelles are endowed with a mitochondrial nitric oxide (NO·) synthase …

Nitric oxide (NO) and its derivatives inhibit mitochondrial respiration by a variety of means.
Nanomolar concentrations of NO immediately, specifically and reversibly inhibit cytochrome …

Eukaryotic cells respond to low-oxygen concentrations by upregulating hypoxic nuclear
genes (hypoxic signaling). Although it has been shown previously that the mitochondrial …

BACKGROUND: Nitric oxide (NO) exerts powerful physiological effects through guanylate
cyclase (GC), a non-mitochondrial enzyme, and through the generation of protein cysteinyl …

Nitric oxide (NO) has been known for many years to bind to cytochrome C oxidase, the
terminal acceptor in the mitochondrial electron transport chain, in competition with oxygen …

The effects of endogenous production of NO•, catalysed by the mitochondrial nitric oxide
synthase (NOS), on mitochondrial metabolism were studied. The respiratory rates of intact …

Nitric oxide synthases (NOS) are the enzymes responsible for nitric oxide (NO) generation.
To date, 3 distinct NOS isoforms have been identified: neuronal NOS (NOS1), inducible NOS …

The accumulated ultrastructural and biochemical evidence is highly suggestive of the
existence of mitochondrial nitric oxide (NO) synthase (mtNOS), where local production of NO …

Neuronal nitric-oxide synthase (NOS-1) is a hemeprotein that generates NO and citrulline
from L-arginine, O 2, and NADPH. During catalysis, a majority of NOS-1 binds self …