It is now recognized that mitochondria play an integral role in orchestrating the response of
the cell to a wide variety of metabolic and environmental stressors. Of particular interest are …

Mitochondria are the specialized organelles for energy metabolism but also participate in
the production of O2 active species, cell cycle regulation, apoptosis and thermogenesis …

Cardiovascular diseases encompass a wide spectrum of abnormalities with diverse
etiologies. The molecular mechanisms underlying these disorders include a variety of …

Endogenous nitric oxide (NO) generated from l-arginine by NO synthase regulates
mitochondrial function by binding to cytochrome c oxidase in competition with oxygen. This …

Both reversible and irreversible inhibition of mitochondrial respiration have been reported
following the generation of nitric oxide (NO) by cells. Using J774 cells, we have studied the …

Attention has focused on particular neurons as the source of nitric oxide (NO) within the
parenchyma of the CNS. In contrast, glial cells have been viewed mainly as potential …

Nitric oxide (NO) is a signaling molecule synthesized from l‐arginine by NO synthase in
animals. Increasing evidence shows that NO regulates the mammalian metabolism of …

The identification, more than 50 years ago, of mitochondria as the site of oxidative energy
metabolism has prompted studies that have unraveled the complexity of the numerous …

Heart mitochondria play a central role in cell energy provision and in signaling. Nitric oxide
(NO) is a free radical with primary regulatory functions in the heart and involved in a broad …

Introduction 3. Nitric oxide production and consumption by mitochondria 4. Nitric oxide
stimulates mitochondrial biogenesis 5. Reversible NO inhibition of cytochrome oxidase 6 …