Modeling the evolution of ETV6-RUNX1–induced B-cell precursor acute lymphoblastic leukemia in mice
L van der Weyden, G Giotopoulos… - Blood, The Journal …, 2011 - ashpublications.org
Abstract The t (12; 21) translocation that generates the ETV6-RUNX1 (TEL-AML1) fusion
gene, is the most common chromosomal rearrangement in childhood cancer and is …
gene, is the most common chromosomal rearrangement in childhood cancer and is …
ETV6/RUNX1 induces reactive oxygen species and drives the accumulation of DNA damage in B cells
HP Kantner, W Warsch, A Delogu, E Bauer… - Neoplasia, 2013 - Elsevier
Abstract The t (12; 21)(p13; q22) chromosomal translocation is the most frequent
translocation in childhood B cell precursor-acute lymphoblastic leukemia and results in the …
translocation in childhood B cell precursor-acute lymphoblastic leukemia and results in the …
Five percent of healthy newborns have an ETV6-RUNX1 fusion as revealed by DNA-based GIPFEL screening
D Schäfer, M Olsen, D Lähnemann… - Blood, The Journal …, 2018 - ashpublications.org
Pediatric acute lymphoblastic leukemia (ALL) is characterized by recurrent preleukemic
chromosomal translocations that emerge frequently in utero. 1 The most common …
chromosomal translocations that emerge frequently in utero. 1 The most common …
The impact of TEL-AML1 (ETV6-RUNX1) expression in precursor B cells and implications for leukaemia using three different genome-wide screening methods
Y Linka, S Ginzel, M Krüger, A Novosel… - Blood cancer …, 2013 - nature.com
Abstract The reciprocal translocation t (12; 21)(p13; q22), the most common structural
genomic alteration in B-cell precursor acute lymphoblastic leukaemia in children, results in a …
genomic alteration in B-cell precursor acute lymphoblastic leukaemia in children, results in a …
Clonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukemia
FW Van Delft, S Horsley, S Colman… - Blood, The Journal …, 2011 - ashpublications.org
B-cell precursor childhood acute lymphoblastic leukemia with ETV6-RUNX1 (TEL-AML1)
fusion has an overall good prognosis, but relapses occur, usually after cessation of …
fusion has an overall good prognosis, but relapses occur, usually after cessation of …
Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice
S Tsuzuki, M Seto, M Greaves… - Proceedings of the …, 2004 - National Acad Sciences
The t (12; 21) translocation, which generates the TEL-AML1 (ETV6-RUNX1) fusion gene, is
the most common structural chromosome change in childhood cancer and is exclusively …
the most common structural chromosome change in childhood cancer and is exclusively …
[HTML][HTML] Autophagy inhibition as a potential future targeted therapy for ETV6-RUNX1-driven B-cell precursor acute lymphoblastic leukemia
R Polak, MB Bierings, CS van der Leije… - …, 2019 - ncbi.nlm.nih.gov
Abstract Translocation t (12; 21), resulting in the ETV6-RUNX1 (or TEL-AML1) fusion protein,
is present in 25% of pediatric patients with B-cell precursor acute lymphoblastic leukemia …
is present in 25% of pediatric patients with B-cell precursor acute lymphoblastic leukemia …
Mechanism of ETV6-RUNX1 leukemia
A Sundaresh, O Williams - RUNX Proteins in Development and Cancer, 2017 - Springer
Abstract The t (12; 21)(p13; q22) translocation is the most frequently occurring single genetic
abnormality in pediatric leukemia. This translocation results in the fusion of the ETV6 and …
abnormality in pediatric leukemia. This translocation results in the fusion of the ETV6 and …
[HTML][HTML] Pathogenesis of ETV6/RUNX1-positive childhood acute lymphoblastic leukemia and mechanisms underlying its relapse
C Sun, L Chang, X Zhu - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract ETV6/RUNX1 (E/R) is the most common fusion gene in childhood acute
lymphoblastic leukemia (ALL). Multiple lines of evidence imply a “two-hit” model for the …
lymphoblastic leukemia (ALL). Multiple lines of evidence imply a “two-hit” model for the …
Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5 +/− leukemia
Background B-cell precursor acute lymphoblastic leukemia (B-ALL) is amongst the leading
causes of childhood cancer-related mortality. Its most common chromosomal aberration is …
causes of childhood cancer-related mortality. Its most common chromosomal aberration is …