Children with Down syndrome (DS) have a markedly increased risk of acute lymphoblastic
leukemia (ALL) and acute myeloid leukemia (AML). To identify chromosomal changes …

Twenty‐eight children with Down syndrome (DS) and acute lymphocytic leukemia (ALL)
were compared to non‐DS control leukemics matched by age, white blood cell (WBC) count …

Previous cytogenetic studies of myeloid and acute lymphoblastic leukemias in children with
Down syndrome (ML‐DS and DS‐ALL) have revealed significant differences in abnormality …

Chromosome and cytologic studies were performed on three Down's syndrome (DS)
patients with acute nonlymphocytic leukemia (ANLL). All three patients had an aneuploid …

The patterns of malignancies in Down syndrome (DS) are unique and highlight the
relationship between chromosome 21 and cancer. DS children have a∼ 10-to 20-fold …

Down in 1866 published his study “Observations on an Ethnic Classification of Idiots,”
describing the characteristic features of a syndrome linking his name to the genetic disorder …

Acute lymphoblastic leukaemia in children with Down syndrome (ALL‐DS) is characterised
by unique clinical and biological features. Notable among these are an absence of ALL in …

We assessed the outcome of children with Down syndrome (DS) and acute lymphoblastic
leukemia (ALL) receiving contemporary risk-based therapy by evaluating clinical and …

Purpose: Children with Down syndrome (DS) carry an elevated risk of developing clonal
hematologic disorders. In this review, we summarize reported data describing the incidence …

In recent pediatric trials of acute myeloid leukemia (AML), children with Down syndrome
(DS) have had significantly more megakaryoblastic leukemia and have experienced better …