VEGF-A regulates cellular localization of SR-BI as well as transendothelial transport of HDL but not LDL
S Velagapudi, M Yalcinkaya… - … , and vascular biology, 2017 - Am Heart Assoc
Objective—Low-and high-density lipoproteins (LDL and HDL) must pass the endothelial
layer to exert pro-and antiatherogenic activities, respectively, within the vascular wall …
layer to exert pro-and antiatherogenic activities, respectively, within the vascular wall …
Transendothelial transport of lipoproteins
The accumulation of low-density lipoproteins (LDL) in the arterial wall plays a pivotal role in
the initiation and pathogenesis of atherosclerosis. Conversely, the removal of cholesterol …
the initiation and pathogenesis of atherosclerosis. Conversely, the removal of cholesterol …
[HTML][HTML] Scavenger receptor BI promotes cytoplasmic accumulation of lipoproteins in clear-cell renal cell carcinoma
S Velagapudi, P Schraml, M Yalcinkaya, HA Bolck… - Journal of lipid …, 2018 - ASBMB
Clear-cell renal cell carcinomas (ccRCCs) are characterized by inactivation of the von
Hippel-Lindau (VHL) gene and intracellular lipid accumulation by unknown …
Hippel-Lindau (VHL) gene and intracellular lipid accumulation by unknown …
[HTML][HTML] Endothelial transcytosis of lipoproteins in atherosclerosis
Seminal studies from Nikolai Anichckov identified the accumulation of cholesterol in the
arteries as the initial event that lead to the formation of atherosclerotic plaques. Further …
arteries as the initial event that lead to the formation of atherosclerotic plaques. Further …
[HTML][HTML] The endothelium is both a target and a barrier of HDL's protective functions
The vascular endothelium serves as a barrier between the intravascular and extravascular
compartments. High-density lipoproteins (HDL) have two kinds of interactions with this …
compartments. High-density lipoproteins (HDL) have two kinds of interactions with this …
Deletion of lymphangiogenic and angiogenic growth factor VEGF-D leads to severe hyperlipidemia and delayed clearance of chylomicron remnants
A Tirronen, T Vuorio, S Kettunen… - … and Vascular Biology, 2018 - Am Heart Assoc
Objective—Dyslipidemia is one of the key factors behind coronary heart disease. Blood and
lymphatic vessels play pivotal roles in both lipoprotein metabolism and development of …
lymphatic vessels play pivotal roles in both lipoprotein metabolism and development of …
LDL attenuates VEGF-induced angiogenesis via mechanisms involving VEGFR2 internalization and degradation following endosome-trans-Golgi network trafficking
F Jin, N Hagemann, U Brockmeier, ST Schäfer… - Angiogenesis, 2013 - Springer
Considerable efforts have been made to amplify angiogenesis under conditions of hypoxia
and ischemia by vascular endothelial growth factor (VEGF) delivery, so far with limited …
and ischemia by vascular endothelial growth factor (VEGF) delivery, so far with limited …
High-density lipoprotein promotes endothelial cell migration and reendothelialization via scavenger receptor-B type I
D Seetharam, C Mineo, AK Gormley, LL Gibson… - Circulation …, 2006 - Am Heart Assoc
Vascular disease risk is inversely related to circulating levels of high-density lipoprotein
(HDL) cholesterol. However, the mechanisms by which HDL provides vascular protection …
(HDL) cholesterol. However, the mechanisms by which HDL provides vascular protection …
[HTML][HTML] HDL-mediated lipid influx to endothelial cells contributes to regulating intercellular adhesion molecule (ICAM)-1 expression and eNOS phosphorylation
M Muñoz-Vega, F Massó, A Páez… - International journal of …, 2018 - mdpi.com
Reverse cholesterol transport (RCT) is considered as the most important antiatherogenic
role of high-density lipoproteins (HDL), but interventions based on RCT have failed to …
role of high-density lipoproteins (HDL), but interventions based on RCT have failed to …
Apolipoprotein M and sphingosine-1-phosphate receptor 1 promote the transendothelial transport of high-density lipoprotein
S Velagapudi, L Rohrer, F Poti… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: ApoM enriches S1P (sphingosine-1-phosphate) within HDL (high-density
lipoproteins) and facilitates the activation of the S1P1 (S1P receptor type 1) by S1P, thereby …
lipoproteins) and facilitates the activation of the S1P1 (S1P receptor type 1) by S1P, thereby …