A20 negatively regulates inflammation by inhibiting the nuclear factor κB (NF-κB)
transcription factor in the tumor necrosis factor–receptor (TNFR) and Toll-like receptor (TLR) …

A20 is a cytoplasmic zinc finger protein that inhibits nuclear factor κB (NF-κB) activity and
tumor necrosis factor (TNF)–mediated programmed cell death (PCD). TNF dramatically …

NF-κB transcription factors mediate the effects of pro-inflammatory cytokines such as tumour
necrosis factor-α and interleukin-1β. Failure to downregulate NF-κB transcriptional activity …

A20 is a cytoplasmic protein required for the termination of tumor necrosis factor (TNF)–
induced signals. We show here that mice doubly deficient in either A20 and TNF or A20 and …

The proinflammatory cytokine interleukin-17 (IL-17) is the signature cytokine of the T helper
17 (TH17) subset of CD4+ T cells, and antibodies targeting IL-17 or the IL-17 receptor (IL …

A20 has been suggested to limit NF‐κB activation by removing regulatory ubiquitin chains
from ubiquitinated substrates. A20 is a ubiquitin‐editing enzyme that removes K 63‐linked …

Deregulation of the transcription factor NF-κB can mediate several inflammatory diseases in
addition to cancer. Therefore, several proteins, including the zinc finger protein A20, tightly …

Inactivation of the TNFAIP3 gene, encoding the A20 protein, is associated with critical
inflammatory diseases including multiple sclerosis, rheumatoid arthritis and Crohn's …

The RING domain protein RNF11 is overexpressed in breast cancers and promotes tumour
growth factor‐beta (TGF‐β) signalling. RNF11 has been proposed to regulate TGF‐β …

The ubiquitin-editing enzyme A20 is a critical negative regulator of inflammation and
cytokine-mediated activation of the transcription factor NF-κB; however, little is known about …