The interstitium of the myocardium is composed of predominantly type I collagen; type III
collagen is present to a lesser extent. The fibrillar collagens serve as tethers between …

Composed of type I and III collagens, the valve leaflets, chordae tendineae and collagen
matrix of the myocardium form a structural continuum. Synthesized by cardiac fibroblasts …

A collagen network, composed largely of type I and III fibrillar collagens, is found in the
extracellular space of the myocardium. This network has multiple functions which includes a …

ymptomatic heart failure and sudden cardiac death are worldwide health problems. In the
hopes of reducing S the morbidity and mortality associated with myocardial failure and …

The accumulation of collagen within the myocardium is termed fibrosis. In left ventricular
pressure overload a reactive interstitial fibrosis, having distinctive biochemical and structural …

The cardiac interstitium is composed of non-myocyte cells and a structural fibrillar protein
network which plays a dominant role in governing the structure, architecture, and …

Myocardial fibrosis can be defined as an abnormal increase in collagen concentration of
either ventricle. This accumulation of collagen, represented predominantly by fibrillar type I …

The major risk factor associated with the appearance of adverse cardiovascular events and
outcome attributable to cardiovascular disease is left ventricular hypertrophy (LVH). Why this …

The extracellular matrix of the myocardium contains an elaborate structural matrix composed
mainly of fibrillar types I and III collagen. This matrix is responsible for the support and …

Changes in the composition of cardiac tissue develop in hypertensive patients with left
ventricular hypertrophy (ie, hypertensive heart disease) and lead to structural remodeling of …