Schizophrenia is a debilitating mental illness distinguished by positive, negative, and
cognitive symptoms. Pathogenesis begins in early neurodevelopment and leads to …

The pathogenesis of schizophrenia begins in early neurodevelopment and leads to
excitatory-inhibitory imbalance. It is therefore essential that preclinical models used to …

Schizophrenia is a neurodevelopmental disorder affecting about 1% of the population. This
thesis focuses on the development of an animal models of schizophrenia-related …

Schizophrenia is a serious mental illness which is characterized by a range of symptoms,
including hallucinations and delusions, social withdrawal, and cognitive deficits. Brain …

Schizophrenia is a chronic, severe and disabling brain disorder that affects more than 21
million people around the world. Despite a tremendous amount of research effort, the …

A consistent finding in post-mortem schizophrenic brain tissue has been a selective
reduction in a subset of inhibitory GABAergic interneurons containing the calcium-binding …

Schizophrenia is characterized by neuropathological changes in inhibitory GABA
interneurons in the hippocampus (HPC) and medial prefrontal cortex (mPFC)(Benes and …

GABAergic cortical interneurons are important components of cortical microcircuits. Their
alterations are associated with a number of neurological and psychiatric disorders, and are …

A growing body of evidence sheds light on the neurodevelopmental nature of schizophrenia
with symptoms typically emerging during late adolescence or young adulthood. We …

Objective: The onset of schizophrenia symptoms in late adolescence implies a
neurodevelopmental trajectory for the disease. Indeed, the γ-aminobutyric acid (GABA) …