Role of genetics in pediatric inflammatory bowel disease

DT Okou, S Kugathasan - Inflammatory bowel diseases, 2014 - academic.oup.com
Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD), ulcerative colitis
(UC), and unclassified IBD, is characterized by chronic intestinal inflammation and has a …

Pediatric inflammatory bowel disease: clinical and molecular genetics

V Biank, U Broeckel… - Inflammatory bowel …, 2007 - academic.oup.com
Pediatric-onset inflammatory bowel disease (IBD) is characterized by distinct phenotypic
differences compared to adult-onset IBD. This raises the question whether early (pediatric) …

Very early-onset inflammatory bowel disease: gaining insight through focused discovery

CJ Moran, C Klein, AM Muise… - Inflammatory bowel …, 2015 - academic.oup.com
The pathogenesis of pediatric inflammatory bowel disease (IBD) is only partially understood.
Strong evidence implicates a strong genetic component including high monozygotic twin …

[HTML][HTML] Inflammatory bowel disease: pathogenesis

YZ Zhang, YY Li - World journal of gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is
characterized by chronic relapsing intestinal inflammation. It has been a worldwide health …

Genetic Defects in Early-Onset Inflammatory Bowel Disease

AOB Dagci, KC Cushing - Rheumatic Disease Clinics, 2023 - rheumatic.theclinics.com
Inflammatory bowel disease (IBD) is a group of complex, multifactorial disorders
characterized by chronic inflammation of the gastrointestinal tract. The three subtypes of IBD …

Distinct phenotype of early childhood inflammatory bowel disease

T Paul, A Birnbaum, DK Pal, N Pittman… - Journal of clinical …, 2006 - journals.lww.com
Distinct Phenotype of Early Childhood Inflammatory Bowel Dis... : Journal of Clinical
Gastroenterology Distinct Phenotype of Early Childhood Inflammatory Bowel Disease …

Etiopathogenesis of inflammatory bowel disease: the importance of the pediatric perspective

M Oliva-Hemker, C Fiocchi - Inflammatory bowel diseases, 2002 - academic.oup.com
Inflammatory bowel disease (IBD) is now recognized as a common chronic disease affecting
children and adolescents. This article will review recent advances made in the fields of …

Inflammatory bowel disease: genetics, epigenetics, and pathogenesis

I Loddo, C Romano - Frontiers in immunology, 2015 - frontiersin.org
Inflammatory bowel diseases (IBDs) are complex, multifactorial disorders characterized by
chronic relapsing intestinal inflammation. Although etiology remains largely unknown, recent …

Genetic determinants of pediatric inflammatory bowel disease: is age of onset genetically determined?

R Scherr, J Essers, H Hakonarson, S Kugathasan - Digestive Diseases, 2009 - karger.com
Inflammatory bowel disease (IBD) is thought to develop as a result of dysregulation of the
immune response to normal gut flora in a genetically susceptible host. Approximately 25% of …

The genetics of inflammatory bowel disease

RH Duerr - Gastroenterology Clinics, 2002 - gastro.theclinics.com
CrohnÕs disease and ulcerative colitis are the chronic, relapsing, and remitting major forms
of idiopathic inflammatory bowel disease (IBD) that affect males and females with a peak …