Measuring conductance switching in single proteins using quantum tunneling

L Tang, L Yi, T Jiang, R Ren… - Science …, 2022 - science.org
Interpreting the electrical signatures of single proteins in electronic junctions has facilitated a
better understanding of the intrinsic properties of proteins that are fundamental to chemical …

Fabrication of electron tunneling probes for measuring single-protein conductance

T Jiang, L Yi, X Liu, AP Ivanov, JB Edel, L Tang - Nature Protocols, 2023 - nature.com
Studying the electrical properties of individual proteins is a prominent research area in the
field of bioelectronics. Electron tunnelling or quantum mechanical tunnelling (QMT) probes …

Observation of giant conductance fluctuations in a protein

B Zhang, W Song, P Pang, Y Zhao, P Zhang… - Nano …, 2017 - iopscience.iop.org
Proteins are insulating molecular solids, yet even those containing easily reduced or
oxidized centers can have single-molecule electronic conductances that are too large to …

Role of contacts in long-range protein conductance

B Zhang, W Song, P Pang, H Lai… - Proceedings of the …, 2019 - National Acad Sciences
Proteins are widely regarded as insulators, despite reports of electrical conductivity. Here we
use measurements of single proteins between electrodes, in their natural aqueous …

Solid-state protein junctions: Cross-laboratory study shows preservation of mechanism at varying electronic coupling

S Mukhopadhyay, SK Karuppannan, C Guo, JA Fereiro… - Iscience, 2020 - cell.com
Successful integration of proteins in solid-state electronics requires contacting them in a non-
invasive fashion, with a solid conducting surface for immobilization as one such contact. The …

Single-molecular protein-based bioelectronics via electronic transport: fundamentals, devices and applications

T Jiang, BF Zeng, B Zhang, L Tang - Chemical Society Reviews, 2023 - pubs.rsc.org
Biomolecular electronics is a rapidly growing multidisciplinary field that combines biology,
nanoscience, and engineering to bridge the two important fields of life sciences and …

Protein bioelectronics: A review of what we do and do not know

CD Bostick, S Mukhopadhyay, I Pecht… - Reports on Progress …, 2018 - iopscience.iop.org
We review the status of protein-based molecular electronics. First, we define and discuss
fundamental concepts of electron transfer and transport in and across proteins and …

Bioengineering a single-protein junction

MP Ruiz, AC Aragonès, N Camarero… - Journal of the …, 2017 - ACS Publications
Bioelectronics moves toward designing nanoscale electronic platforms that allow in vivo
determinations. Such devices require interfacing complex biomolecular moieties as the …

Probing bioelectronic connections using streptavidin molecules with modified valency

B Zhang, E Ryan, X Wang… - Journal of the American …, 2021 - ACS Publications
As molecular electronic components, proteins are distinguished by a remarkably long
electronic decay length (∼ 10 nm) together with high contact resistance and extreme …

Molecular bioelectronics

JJ Davis, DA Morgan, CL Wrathmell… - Journal of Materials …, 2005 - pubs.rsc.org
Recent work by a number of groups has highlighted the emerging potential associated with
the marriage of nanoscale electronics and biological structure. Many biological …