A small subgroup of patients with asthma suffers from severe disease that is either partially
controlled or uncontrolled despite intensive, guideline-based treatment. These patients have …

ABSTRACT RATIONALE: While severe asthma affects approximately 5% of all individuals
with asthma, this small minority of individuals accounts for a large proportion of the asthma …

Asthma is a heterogeneous disease in which adequate asthma control cannot be achieved
in a substantial proportion despite currently available treatment possibilities. This subgroup …

Severe asthma is a heterogeneous and often difficult to treat condition that results in a
disproportionate cost to healthcare systems. Appropriate diagnosis and management of …

Asthma is a chronic respiratory disease characterized by respiratory symptoms, airway
inflammation, airway obstruction and airway hyper‐responsiveness. Asthma is common and …

Background: Patients with severe persistent asthma comprise only 5-10% of the total asthma
population, but account for a large proportion of asthma morbidity and health care …

In recent decades, the concept of severe asthma has evolved from an umbrella term
encompassing patients with high-intensity treatment needs to a clinical syndrome with …

Asthma is a common disease, and although its clinical manifestations may be similar among
patients, recent research discoveries have shown that it consists of several distinct clinical …

Severe asthma is widely recognized as a major unmet need. It is defined as asthma that
requires treatment with high-dose inhaled corticosteroids and a second controller and/or …

Key points Not all patients with “difficult-to-control” asthma have “severe asthma”. Many of
them have either an incorrect diagnosis, or mild-moderate asthma with unrecognised …