The three‐dimensional structure of a bacterial superantigen, Staphylococcus aureus
enterotoxin H (SEH), bound to human major histocompatibility complex (MHC) class II (HLA …

The structure of a bacterial superantigen, Staphylococcus aureus enterotoxin B, bound to a
human class II histocompatibility complex molecule (HLA-DR1) has been determined by X …

The X-ray structure of the superantigen staphylococcal enterotoxin H (SEH) has been
determined at 1.69 Å resolution. In this paper we present two structures of zinc-free SEH …

MHC class II molecules possess two binding sites for bacterial superantigens (SAGs): a low-
affinity site on the α chain and a high-affinity, zinc-dependent site on the β chain. Only the …

Superantigens form complexes with major histocompatibility complex (MHC) class II
molecules and T-cell receptors resulting in extremely strong immunostimulatory properties …

Superantigens are bacterial or viral proteins that elicit massive T cell activation through
simultaneous binding to major histocompatibility complex (MHC) class II and T cell …

Staphylococcal enterotoxin B is a member of a family of toxins known as superantigens that
activate a large number of T-cells (up to 20%) by cross-linking MHC class II molecules with T …

Superantigens are thought to make external contacts with major histocompatibility complex
(MHC) class II molecules and with the V beta portion of a T cell antigen receptor (TCR) …

Streptococcal superantigen (SSA) is a 28,000 M r toxin originally isolated from a pathogenic
strain of Streptococcus pyogenes that has 60% sequence identity with staphylococcal …

Bacterial superantigens are small proteins that have a very potent stimulatory effect on T
lymphocytes through their ability to bind to both MHC class II molecules and T-cell receptors …