While recent evidence strongly suggests that the third complementarity determining regions
(CDR3s) of T cell receptors (TCRs) directly contact antigenic peptides bound to major …

The alpha-and beta-chains of the heterodimeric major histocompatibility complex molecules
HLA-DRB5* 0101 and DRB1* 0101 were expressed separately in Escherichia coli. The …

Superantigens, in association with class II major histocompatibility complex (MHC)
molecules, activate T cells bearing particular beta chain variable domains of the T cell …

Staphylococcal enterotoxins (SE) activate human T cells in vitro. This requires the presence
of Ia+ accessory cells but does not require processing of the toxin by the accessory cell. We …

Srxyears have passed since publication1 of the three-dimensional structure of a class I
molecule of the major histocompatibility complex (MHC). On page 33 of this issue2 we are …

The three‐dimensional structures of three human and two murine class I molecules, in
complex with single peptides and with mixtures of endogenous peptides, have now been …

Superantigen recognition by some T cells is strongly influenced by polymorphic residues of
the MHC class II molecule, suggesting that the TCR contacts the class II molecule during …

The invariant chain is a membrane protein associated with the major histocompatibility
complex class II antigens both intra-and extracellularly. The extracellular portion of the …

New structures of MHC molecules have significantly improved our understanding of
molecular recognition in cellular immunology. Highlights include the first structure of a class …