Mitochondria, the site of oxidative energy metabolism in eukariotic cells, are a highly
organised structure endowed with different enzymes and reactions localized in discrete …

Nitric oxide (NO) is an intercellular signaling molecule; among its many and varied roles are
the control of blood flow and blood pressure via activation of the heme enzyme, soluble …

The effect of O2 concentration on mitochondrial nitric oxide synthase (mtNOS) activity and
on O2− production was determined in rat liver, brain, and kidney submitochondrial …

Nitric oxide (NO) reversibly inhibits mitochondrial respiration by competing with oxygen at
cytochrome oxidase. Concentrations of NO measured in a range of biological systems are …

Nitric oxide (NO•) signaling is diverse, and involves reaction with free radicals,
metalloproteins, and specific protein amino acid residues. Prominent among these …

Biological systems that produce or are exposed to nitric oxide (NO⋅) exhibit changes in the
rate of oxygen free radical production. Considering that mitochondria are the main …

NO (nitric oxide) can affect mitochondrial function by interacting with the cytochrome c
oxidase (complex IV) of the electron transport chain in a manner that is reversible and in …

New discoveries in the last decade significantly altered our view on mitochondria. They are
no longer viewed as energy-making slaves but rather individual cells-within-the-cell. In …

Nitric oxide (NO) is produced in mam‐mals by different isoforms of NO synthase (NOS), in‐
cluding the constitutive mitochondrial enzyme (mtNOS). Here we demonstrate that the …

Nitric oxide (NO) exerts a wide range of its biological properties via its interaction with
mitochondria. By competing with O2, physiologically relevant concentrations of NO …