Targeting of hepatic macrophages by therapeutic nanoparticles

CI Colino, JM Lanao, C Gutierrez-Millan - Frontiers in immunology, 2020 - frontiersin.org
Hepatic macrophage populations include different types of cells with plastic properties that
can differentiate into diverse phenotypes to modulate their properties in response to different …

Targeting distinct myeloid cell populations in vivo using polymers, liposomes and microbubbles

C Ergen, F Heymann, F Gremse, M Bartneck, U Panzer… - Biomaterials, 2017 - Elsevier
Identifying intended or accidental cellular targets for drug delivery systems is highly relevant
for evaluating therapeutic and toxic effects. However, limited knowledge exists on the …

Physicochemical and biological aspects of macrophage‐mediated drug targeting in anti‐microbial therapy

S Kunjachan, S Jose, CA Thomas… - Fundamental & …, 2012 - Wiley Online Library
Macrophages are important drug targets as they mediate a wide variety of infectious
diseases. Visceral leishmaniasis (VL), schistosomiasis, brucellosis, and salmonellosis are …

Particle engineering to enhance or lessen particle uptake by alveolar macrophages and to influence the therapeutic outcome

B Patel, N Gupta, F Ahsan - European Journal of Pharmaceutics and …, 2015 - Elsevier
The alveolar macrophages defend the lung against airborne pollutants and infectious
microorganisms. Recent advances in the understanding of the role of macrophages in …

Drug delivery strategies to control macrophages for tissue repair and regeneration

R Garash, A Bajpai… - Experimental biology …, 2016 - journals.sagepub.com
Tissue repair and regeneration is a complex process. Our bodies have an excellent capacity
to regenerate damaged tissues in many situations. However, tissue healing is impaired in …

Macrophages as targets for delivery of liposome-encapsulated antimicrobial agents

CR Alving - Advanced Drug Delivery Reviews, 1988 - Elsevier
Macrophages are particularly effective in dealing with microorganisms that cause chronic
and intracellular infectious diseases and with organisms that have eluded killing by …

Micro and nanoparticle‐based delivery systems for vaccine immunotherapy: an immunological and materials perspective

J Leleux, K Roy - Advanced healthcare materials, 2013 - Wiley Online Library
The development and widespread application of vaccines has been one of the most
significant achievements of modern medicine. Vaccines have not only been instrumental in …

Transient suppression of macrophage functions by liposome-encapsulated drugs

N van Rooijen, J Bakker, N Sanders - Trends in biotechnology, 1997 - cell.com
Macrophages play an important role in host defense reactions, for example, by phagocytosis
of particulate materials. This process also results in the rapid removal of targeting devices …

Particulate delivery systems for vaccines: what can we expect?

VW Bramwell, Y Perrie - Journal of pharmacy and …, 2006 - Wiley Online Library
In our attempts to thwart the unwanted attentions of microbes by prophylactic and
therapeutic vaccination, the knowledge of interactions at the molecular level may prove to be …

Nanoparticle internalization promotes the survival of primary macrophages

BM Jarai, CA Fromen - Advanced nanobiomed research, 2022 - Wiley Online Library
Macrophages, a class of tissue resident innate immune cells, are responsible for
sequestering foreign objects through the process of phagocytosis, making them a promising …