Steroid hormones are known systemic regulators of multiple normal and cancerous tissues;
however, whether or how they impact the fate and function of adult stem cells is unclear. In …

It is known that signaling from the germline stem cell niche is required to maintain germline
stem cell identity in Drosophila. However, it is not clear whether the germline stem-cell …

Highly potent animal stem cells either self renew or launch complex differentiation programs,
using mechanisms that are only partly understood. Drosophila female germline stem cells …

Previously, it has been shown that in Drosophila steroid hormones are required for
progression of oogenesis during late stages of egg maturation. Here, we show that …

Stem cell regulation by local signals is intensely studied, but less is known about the effects
of hormonal signals on stem cells. In Drosophila, the primary steroid twenty …

Drosophila adult females but not males contain high levels of the steroid hormone
ecdysone, however, the roles played by steroid signaling during Drosophila gametogenesis …

Stem cells must proliferate while maintaining 'stemness'; however, much remains to be
learned about how factors that control the division of stem cells influence their identity …

Multiple aspects of Drosophila oogenesis, including germline stem cell activity, germ cell
differentiation, and follicle survival, are regulated by the steroid hormone ecdysone. While …

Abstract Purpose of Review Stem cells respond to local paracrine signals; more recently,
however, systemic hormones have also emerged as key regulators of stem cells. This review …

In this study, we uncover a role for microRNAs (miRNAs) in Drosophila germline stem cell
(GSC) maintenance. Disruption of Dicer-1 function in GSCs during adult life results in GSC …