Spermatogenesis in Drosophila commences with cell division of germline stem cells (GSCs)
to produce male germline cells at the tip of the testis. However, molecular mechanisms …

Local signals maintain adult stem cells in many tissues. Whether the sexual identity of adult
stem cells must also be maintained was not known. In the adult Drosophila testis niche, local …

Stem cell niche is a specialized microenvironment crucial for stem cell self-renewal.
Drosophila testis contains two types of stem cells: germline stem cells (GSCs) and somatic …

It is important to understand the regulation of stem cell division because defects in this
process can cause altered tissue homeostasis or cancer. The cyclin-dependent kinase …

Stem cells reside in niches that provide signals to maintain self-renewal, and differentiation
is viewed as a passive process that depends on loss of access to these signals. Here, we …

Embryonic stem cells (ESCs) are defined by two essential features—pluripotency and self-
renewal—whose balance requires the concerted action of signal transduction pathways …

Tight regulation of stem cell proliferation is fundamental to tissue homeostasis, aging and
tumor suppression. Although stem cells are characterized by their high potential to …

In many tissues, two or more types of stem cells share a niche, and how the stem cells
coordinate their self‐renewal and differentiation is poorly understood. In the Drosophila …

Tissue-specific stem cells and their niches are organized into functional units that respond to
external cues in order to maintain organ homeostasis. Insulin and Target of rapamycin (Tor) …

Epithelial stem cells divide asymmetrically, such that one daughter replenishes the stem cell
pool and the other differentiates. We found that, in the epithelial follicle stem cell (FSC) …