Detecting the molecular system signatures of idiopathic pulmonary fibrosis through integrated genomic analysis

I Gangwar, N Kumar Sharma, G Panzade, S Awasthi… - Scientific reports, 2017 - nature.com
Abstract Idiopathic Pulmonary Fibrosis (IPF) is an incurable progressive fibrotic disease of
the lungs. We currently lack a systematic understanding of IPF biology and a systems …

Integrative analysis of lung molecular signatures reveals key drivers of idiopathic pulmonary fibrosis

SK Kim, SM Jung, KS Park, KJ Kim - BMC Pulmonary Medicine, 2021 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a devastating disease with a high clinical
burden. The molecular signatures of IPF were analyzed to distinguish molecular subgroups …

Identification of key candidate genes involved in the progression of idiopathic pulmonary fibrosis

Y Cui, J Ji, J Hou, Y Tan, X Han - Molecules, 2021 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a lethal, agnogenic interstitial lung disease with limited
therapeutic options. To investigate vital genes involved in the development of IPF, we …

Integrative analysis reveals the recurrent genetic etiologies in idiopathic pulmonary fibrosis

S Guo, Y Dong, C Wang, Y Jiang… - … Journal of Medicine, 2023 - academic.oup.com
Background Idiopathic pulmonary fibrosis (IPF) is increasingly recognized as a chronic,
progressive and fatal lung disease with an unknown etiology. Current studies focus on …

Cluster analysis of transcriptomic datasets to identify endotypes of idiopathic pulmonary fibrosis

LM Kraven, AR Taylor, PL Molyneaux, TM Maher… - Thorax, 2023 - thorax.bmj.com
Background Considerable clinical heterogeneity in idiopathic pulmonary fibrosis (IPF)
suggests the existence of multiple disease endotypes. Identifying these endotypes would …

Integrative analyses of genes associated with idiopathic pulmonary fibrosis

H Wang, Q Xie, W Ou‐Yang… - Journal of Cellular …, 2019 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF), characterized by irreversible scarring and progressive
destruction of the lung tissue, is one of the most common types of idiopathic interstitial …

Gene correlation network analysis to identify regulatory factors in idiopathic pulmonary fibrosis

JE McDonough, N Kaminski, B Thienpont, JC Hogg… - Thorax, 2019 - thorax.bmj.com
Background Idiopathic pulmonary fibrosis (IPF) is a severe lung disease characterised by
extensive pathological changes. The objective for this study was to identify the gene network …

Reviews and prospectives of signaling pathway analysis in idiopathic pulmonary fibrosis

Z Yan, Z Ping - Autoimmunity reviews, 2014 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing disease with disappointing
survival rate, and uneffective therapeutic progress has been made in the last few years …

Evolving genomic approaches to idiopathic pulmonary fibrosis: moving beyond genes

DJ Kass, N Kaminski - Clinical and translational science, 2011 - Wiley Online Library
A little more than 10 years ago, the completed sequencing of the human genome boldly
promised to usher in an era of enhanced understanding and accelerated development of …

Integrative analyses for the identification of idiopathic pulmonary fibrosis-associated genes and shared loci with other diseases

M Chen, Y Zhang, T Adams, D Ji, W Jiang, LV Wain… - Thorax, 2023 - thorax.bmj.com
Background Although genome-wide association studies (GWAS) have identified many
genomic regions associated with idiopathic pulmonary fibrosis (IPF), the causal genes and …