Matrix metalloproteinase-7 (MMP-7) is a secreted zinc-and calcium-dependent
endopeptidase that degrades a broad range of extracellular matrix substrates and additional …

Matrix metalloproteinases (MMPs) are members of the neutral proteinase family. They were
previously thought to be anti-fibrotic because of their ability to degrade and remodel of …

Matrix metalloproteinase-7 (MMP-7) is a secreted zinc-dependent endopeptidase that is
implicated in regulating kidney homeostasis and diseases. MMP-7 is produced as an …

Matrix metalloproteinase-9 (MMP-9) is one of the major components of the matrix proteolytic
network, and its role in the pathogenesis of renal interstitial fibrosis remains largely …

A pro-fibrotic role of matrix metalloproteinase-9 (MMP-9) in tubular cell epithelial–
mesenchymal transition (EMT) is well established in renal fibrosis; however studies from our …

Chronic kidney disease (CKD) and failure are problems of increasing importance.
Regardless of the primary etiology, CKD is characterized by tubular atrophy, interstitial …

Abstract Matrix metalloproteinase-7 (MMP-7), a secreted zinc–and calcium–dependent
endopeptidase, is a transcriptional target of canonical Wnt/β-catenin signaling. Because …

Background Reduced turnover of extracellular matrix has a role in renal fibrosis. Matrix
metalloproteinases (MMPs) is associated with many glomerular diseases, but the …

Matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinases (ADAMs)
belong to the metzincin family of zinc-containing multidomain molecules, and can act as …

The percentage of the US population over 65 is rapidly increasing, as is the incidence of
chronic kidney disease (CKD). The kidney is susceptible to age‐dependent alterations in …