Progression of diabetic nephropathy to end-stage kidney disease is mediated by a host of
pro-cesses, but none is as important as the gradual, inexorable scarring of the renal …

Renal fibrosis is a hallmark of chronic kidney disease. Although considerable achievements
in the pathogenesis of renal fibrosis have been made, the underlying mechanisms of renal …

Fibrosis is a characteristic feature of all forms of chronic kidney disease. Deposition of
pathological matrix in the interstitial space and within the walls of glomerular capillaries as …

Renal fibrosis is characterized by progressive accumulation of extracellular matrix (ECM)
proteins, resulting in loss of organ function and eventually requiring renal replacement …

Matrix metalloproteinases (MMPs) are members of calcium dependent-zinc containing
endopeptidases that play a pivotal role in extracellular matrix (ECM) remodeling. MMPs are …

Background The extent of renal fibrosis in chronic kidney disease (CKD) is the best predictor
for progression of most renal diseases. To date, no established biomarkers of renal fibrosis …

Matrix metalloproteinases (MMPs) are a group of zinc and calcium endopeptidases which
cleave extracellular matrix (ECM) proteins. They are also involved in the degradation of cell …

Introduction Diabetic kidney disease (DKD) is the most common cause of end-stage renal
disease (ESRD) worldwide. Currently, there is no effective treatment to completely prevent …

Renal fibrosis causes structural and functional impairment of the kidney, which is a dominant
component of chronic kidney disease. Recently, a novel mechanism, macrophage-to …

Epidemiological studies support a strong link between organ fibrosis and epithelial cancers.
Moreover, clinical and experimental investigations consistently indicate that these diseases …