Although drugs that lead to cholesterol and lipid lowering have proved to have significant
effects in lowering cardiovascular morbidity and mortality, coronary artery disease remains a …

Macrophages play a critical role in the development and progression of atherosclerosis.
Depending on their surrounding milieu, macrophages can adopt a wide range of functional …

In atherogenesis, macrophage foam cell formation is modulated by pathways involving both
the uptake and efflux of cholesterol. We recently showed that interleukin-10 (IL-10) …

Atherosclerosis is a chronic inflammatory disease that manifests in multiple vascular beds
and frequently culminates in ischemic events, including myocardial infarction. Blood …

Background: Rheumatoid arthritis (RA) is a chronic systemic autoimmune inflammatory
disorder that increases the risk of developing cardiovascular disease. There is accumulating …

The formation of foam cells is the hallmark of early atherosclerotic lesions, and the uptake of
modified low-density lipoprotein (LDL) by macrophage scavenger receptors is thought to be …

Background Dyslipidemia is a common comorbidity in patients with systemic lupus
erythematosus, it is favored by central obesity, nephrotic syndrome, glucocorticoids and …

Atherosclerotic plaques tend to rupture as a consequence of a weakened fibrous cap,
particularly in the shoulder regions where most macrophages reside. Macrophages express …

OBJECTIVE: Toll-like receptors (TLRs), a group of pathogen-associated microbial pattern
recognition receptors, play an important role in innate immune signaling and are …

Objective Patients with rheumatoid arthritis (RA) are at increased cardiovascular risk. Recent
studies suggest that high-density lipoprotein (HDL) may lose its protective vascular …