OP0234 Clinical and biologic effects of icosl blockade by amg 557 in subjects with lupus arthritis

LE Cheng, Z Amoura, B Cheah, F Hiepe… - Annals of the …, 2017 - search.proquest.com
Background Blockade of inducible costimulatory ligand (ICOSL) might be a promising
approach for autoimmune diseases such as systemic lupus erythematosus (SLE). We …

Visceral adipose tissue-derived serine protease inhibitor accelerates cholesterol efflux by up-regulating ABCA1 expression via the NF-κB/miR-33a pathway in THP-1 …

JH Gao, MY Zeng, XH Yu, GF Zeng, LH He… - Biochemical and …, 2018 - Elsevier
Atherosclerosis is a dyslipidemia disease characterized by foam cell formation driven by the
accumulation of lipids. Visceral adipose tissue-derived serine protease inhibitor (vaspin) is …

Toll-like receptors and macrophage activation in atherosclerosis

AN Seneviratne, B Sivagurunathan, C Monaco - Clinica Chimica Acta, 2012 - Elsevier
Atherosclerosis is a multi-factorial inflammatory disease and is the primary initiator of
coronary artery and cerebrovascular disease. Initially believed to be exclusively lipid-driven …

Tauroursodeoxycholic Acid Alleviates Atherosclerosis by Inhibiting AIM2 Inflammasome Activation and Enhancing Cholesterol Efflux Capacity in Macrophage

X Wang, L Du, Y Zhang, Z Jiang, K Wang, X Yin, Y Guo… - papers.ssrn.com
Background: Cholesterol efflux capacity dysfunction in macrophages is thought to be an
important factor in atherosclerosis. However, the molecular mechanism underlying this …

Triglyceride down-regulates matrix metalloprotease-12 expression in THP-1 macrophages through activation of the NF-κB pathway

DH Lee, YS Kim, J Lim, Y Cho, BC Jung, CH Pan… - Genes & Genomics, 2013 - Springer
Triglyceride (TG) is known to be associated with inflammatory diseases including
atherosclerosis. At the cellular level, TG can act as an immunomodulatory stimulus for …

[HTML][HTML] Salicylate improves macrophage cholesterol homeostasis via activation of Ampk

MD Fullerton, RJ Ford, CP McGregor, ND LeBlond… - Journal of lipid …, 2015 - ASBMB
Atherosclerosis stems from imbalances in lipid metabolism and leads to maladaptive
inflammatory responses. The AMP-activated protein kinase (Ampk) is a highly conserved …

[HTML][HTML] Commentary: Monocyte and macrophage lipid accumulation results in down-regulated type-I interferon responses

F Li, H Zhang - Frontiers in Cardiovascular Medicine, 2023 - frontiersin.org
Macrophages possess remarkable phenotypic and functional plasticity in response to micro-
environmental stimuli (1). In atherosclerosis, macrophages sequester extracellular modified …

[HTML][HTML] CLI-095 decreases atherosclerosis by modulating foam cell formation in apolipoprotein E-deficient mice

XQ Wang, HQ Wan, XJ Wei… - Molecular medicine …, 2016 - spandidos-publications.com
Abstract Toll-like receptor 4 (TLR4) is considered to have a critical role in the occurrence
and development of atherosclerosis in atherosclerosis-prone mice; however, it remains …

[引用][C] IDF2022-0723 Interleukin-4 Improves Metabolic Homeostasis by Inhibiting Lipid Deposits and Promoting Macrophage Cholesterol Efflux

MY Shiau, KT Ho, YK Lin… - Diabetes …, 2023 - diabetesresearchclinicalpractice …
Background Sustained inflammation of obesity causes insulin resistance, adipocyte
malfunctions, transformation of adipose tissue-infiltrated macrophages (AIM) from anti …

Modulators of Monocyte and Macrophage Phenotypes in Atherosclerosis

JL Johnson, NP Jenkins - Edited by Sarah Jane George and, 2010 - Wiley Online Library
Host defense systems of multicellular organisms comprise two major arms:(i) the innate and
(ii) the adaptive parts of the immune system. The innate immune system has a humoral arm …