Molecular physiology of P2X receptors
RA North - Physiological reviews, 2002 - journals.physiology.org
P2X receptors are membrane ion channels that open in response to the binding of
extracellular ATP. Seven genes in vertebrates encode P2X receptor subunits, which are 40 …
extracellular ATP. Seven genes in vertebrates encode P2X receptor subunits, which are 40 …
Co-expression of P2X1 and P2X5 receptor subunits reveals a novel ATP-gated ion channel
P2X receptors are a family of ion channels gated by extracellular ATP. Each member of the
family can form functional homomeric channels, but only P2X2 and P2X3 have been shown …
family can form functional homomeric channels, but only P2X2 and P2X3 have been shown …
ATP binding at human P2X1 receptors: contribution of aromatic and basic amino acids revealed using mutagenesis and partial agonists
JA Roberts, RJ Evans - Journal of Biological Chemistry, 2004 - ASBMB
P2X receptors comprise a family of ATP-gated ion channels with the basic amino acids Lys-
68, Arg-292, and Lys-309 (P2X 1 receptor numbering) contributing to agonist potency. In …
68, Arg-292, and Lys-309 (P2X 1 receptor numbering) contributing to agonist potency. In …
Mutational analysis of the conserved cysteines of the rat P2X2 purinoceptor
JD Clyne, LF Wang, RI Hume - Journal of Neuroscience, 2002 - Soc Neuroscience
P2X receptors are ATP-gated cation channels that are widely expressed in the brain. The
extracellular domains of all seven P2X receptors contain 10 conserved cysteines, which …
extracellular domains of all seven P2X receptors contain 10 conserved cysteines, which …
[HTML][HTML] Desensitization of the P2X2 receptor controlled by alternative splicing
U Brändle, P Spielmanns, R Osteroth, J Sim… - FEBS letters, 1997 - Elsevier
P2X receptors are ion channels gated by extracellular ATP. We report here cloning of a
P2X2 receptor splice variant (P2X2-2) carrying a 207 bp deletion in the intracellular C …
P2X2 receptor splice variant (P2X2-2) carrying a 207 bp deletion in the intracellular C …
Biochemical and functional evidence for heteromeric assembly of P2X1 and P2X4 subunits
P2X receptors are ligand‐gated ion channels activated by extracellular ATP. In expression
systems, P2X subunits form homo‐and heterotrimeric receptors. Heteromerization is also …
systems, P2X subunits form homo‐and heterotrimeric receptors. Heteromerization is also …
[HTML][HTML] P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand‐gated ion channels
A Nicke, HG Bäumert, J Rettinger, A Eichele… - The EMBO …, 1998 - embopress.org
P2X receptors are cation channels gated by extracellular ATP. The seven known P2X
isoforms possess no sequence homology with other proteins. Here we studied the …
isoforms possess no sequence homology with other proteins. Here we studied the …
Molecular and functional characterization of human P2X2 receptors
KJ Lynch, E Touma, W Niforatos, KL Kage… - Molecular …, 1999 - ASPET
P2X receptors are a family of ATP-gated ion channels. Four cDNAs with a high degree of
homology to the rat P2X2 receptor were isolated from human pituitary and pancreas RNA …
homology to the rat P2X2 receptor were isolated from human pituitary and pancreas RNA …
Cloning of P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels
Two new P2X receptor cDNAs (P2X5 and P2X6) were isolated and expressed. All six
proteins are 36–48 percent identical and seem to have two transmembrane segments with a …
proteins are 36–48 percent identical and seem to have two transmembrane segments with a …
Signaling at purinergic P2X receptors
A Surprenant, RA North - Annual review of physiology, 2009 - annualreviews.org
P2X receptors are membrane cation channels gated by extracellular ATP. Seven P2X
receptor subunits (P2X1-7) are widely distributed in excitable and nonexcitable cells of …
receptor subunits (P2X1-7) are widely distributed in excitable and nonexcitable cells of …