P2X receptors are ligand-gated ion channels activated by ATP. Early evidence for the role of
extracellular ATP in signalling was based on the ability of ATP and its analogues to contract …

Seven P2X receptor subunits have been cloned which form functional homo-and
heterotrimers. These are cation-selective channels, equally permeable to Na+ and K+ and …

The known seven mammalian receptor subunits (P2X1–7) form cationic channels gated by
ATP. Three subunits compose a receptor channel. Each subunit is a polypeptide consisting …

P2X receptors for ATP are a family of ligand-gated cation channels. There are 11 conserved
positive charges in the extracellular loop of P2X receptors. We have generated point …

The mammalian P2X receptor gene family encodes two-transmembrane domain
nonselective cation channels gated by extracellular ATP. Anatomical localization data …

We have isolated the cDNA for a novel member (P2X6) of the ATP-gated ion channel family.
The rat P2X6nucleotide sequence encodes a 379 amino acid protein that conserves all the …

There are seven P2X receptor cDNAs currently known. Six homomeric (P2X1, P2X2, P2X3,
P2X4, P2X5, P2X7) and three heteromeric (P2X2/P2X3, P2X4/P2X6, P2X1/P2X5) P2X …

P2X receptors are nonselective cation channels gated by extracellular ATP. Recombinant
mammalian P2X subunits assemble in homomeric ionotropic ATP receptors that differ by …

P2X receptors are ATP-gated nonselective cation channels. Functional receptors are
assembled as homotrimers or heterotrimers of seven cloned subunits. Each subunit contains …

P2X receptors are ATP-gated ion channels found in a variety of tissues and cell types.
Seven different subunits (P2X 1-P2X 7) have been molecularly cloned and are known to …