Sphingolipids (SLs) are structural components of the lipid bilayer regulating cell functions. In
biological fluids, their distribution is sex-specific and is at variance in aging and many …

This paper reviews our present knowledge on the contribution of ceramide (Cer),
sphingomyelin (SM), dihydroceramide (DhCer) and sphingosine-1-phosphate (S1P) in …

Despite the advancements in modern medicine, there are still difficulties in diagnosing
common illnesses. The invasiveness and price of the tests used to follow up certain …

Aging is a process leading to a progressive loss of physiological integrity and homeostasis,
and a primary risk factor for many late-onset chronic diseases. The mechanisms underlying …

Sphingolipids (SL) modulate several cellular processes including cell death, proliferation
and autophagy. The conversion of sphingomyelin (SM) to ceramide and the balance …

As centenarians well represent the model of healthy aging, there are many important
implications in revealing the underlying molecular mechanisms behind such successful …

Background and objectives: Alzheimer's disease (AD) is the most common form of dementia
characterized by memory loss and executive dysfunction. To date, no markers can effectively …

Aging is defined as the progressive deterioration of physiological function with age.
Incidence of many pathologies increases with age, including neurological and …

Sphingolipids are an important class of lipids present in all eukaryotic cells that regulate
critical cellular processes. Disturbances in sphingolipid homeostasis have been linked to …

Sphingolipids (SLs) are endogenously bioactive molecules with diverse structures, and its
metabolic disorders are involved in the progression of many diseases. In this study, an ultra …