Understanding of ferritin biology has traditionally centered on its role in iron storage and
homeostasis, with low ferritin levels indicative of deficiency and high levels indicative of …

Iron is an essential element for virtually all cell types due to its role in energy metabolism,
nucleic acid synthesis and cell proliferation. Nevertheless, if free, iron induces cellular and …

Iron is an essential compound for immunosurveillance because of its growth-promoting and
differentiation-inducing properties for immune cells and its interference with cell-mediated …

Iron is an essential trace metal for nearly all infectious microorganisms, and host defense
mechanisms target this dependence to deprive microbes of iron. This review highlights …

Objective A markedly elevated serum ferritin level has been associated with inflammatory
conditions such as adult-onset Still's disease, systemic juvenile idiopathic arthritis, and …

Patients with inflammatory conditions such as inflammatory bowel disease (IBD), chronic
heart failure (CHF), and chronic kidney disease (CKD) have high rates of iron deficiency with …

Iron, an essential element for many important cellular functions in all living organisms, can
catalyze the formation of potentially toxic free radicals. Excessive iron is sequestered by …

Macrophages are central cells both in the immune response and in iron homeostasis. Iron is
both essential and potentially toxic. Therefore, iron acquisition, transport, storage, and …

This report provides perspectives concerning dual roles of serum ferritin as a measure of
both iron status and inflammation. We suggest benefits of a lower range of serum ferritin as …

Iron is an essential micronutrient for virtually all living cells. In infectious diseases, both
invading pathogens and mammalian cells including those of the immune system require iron …