Cells secrete a variety of substances by “regulated exocytosis”(ie, fusion of secretory
vesicles with the plasma membrane) in response to extracellular stimuli. Since two …

The specific transfer of vesicles between organelles is critical in generating and maintaining
the organization of membrane compartments within cells. Syntaxin 6 is a recently discovered …

Many plasma membrane (PM) proteins enter cells nonselectively through clathrin-
independent endocytosis (CIE). Here, we present evidence that cytoplasmic sequences in …

Sec1/Mun18-like (SM) proteins and soluble N-ethylmaleimide-sensitive factor attachment
protein receptors (SNAREs) play central roles in intracellular membrane fusion. Diverse …

Fusion of intracellular trafficking vesicles is mediated by the assembly of SNARE proteins
into membrane-bridging complexes. SNARE-mediated membrane fusion requires …

Eukaryotic cells use conserved multisubunit membrane tethering complexes, including
CORVET (class C core vacuole/endosome tethering) and HOPS (homotypic fusion and …

SNAREs are compartmentally specific membrane proteins required for intracellular
membrane fusion. Homologues of the Saccharomyces cerevisiae protein Seclp interact with …

SNARE proteins control intracellular membrane fusion through formation of membrane-
bridging helix bundles of amphipathic SNARE motifs. Repetitive cycles of membrane fusion …

Sec1p/Munc18 (SM) proteins are essential for SNARE-mediated membrane trafficking. The
formulation of unifying hypotheses for the function of the SM protein family has been …

The Sec1/Munc18 protein family members perform an essential, albeit poorly understood,
function in association with s oluble n-ethylmaleimide sensitive factor a daptor protein re …