Membrane fusion is generally controlled by Rabs, soluble N-ethylmaleimide–sensitive factor
attachment protein receptors (SNAREs), and tethering complexes. Syntaxin 17 (STX17) was …

The roles of the components of the Sec34p protein complex in intracellular membrane
trafficking, first identified in the yeast Saccharomyces cerevisiae, have yet to be …

In budding yeast, the Sec6/8p complex is essential for generating cell polarity by specifying
vesicle delivery to the bud tip. We show that Sec6/8 homologs are components of a …

Vps8 is a subunit of the CORVET tethering complex, which is involved in early-to-late
endosome fusion. Here, we examine the role of Vps8 in membrane fusion at late …

The Zw10 protein, in the context of the conserved Rod–Zwilch–Zw10 (RZZ) complex, is a
kinetochore component required for proper activity of the spindle assembly checkpoint in …

In yeast, the assembly of the target (t)-SNAREs [Tlg2p/Tlg1p, Vti1p] and [Pep12p/Tlg1p,
Vti1p] with the vesicular (v)-SNARE Snc2p promotes endocytic fusion. Here, selected …

Autophagy is a degradative pathway in which cytosolic material is enwrapped within double
membrane vesicles, so-called autophagosomes, and delivered to lytic organelles. SNARE …

Membrane-bound soluble N-ethylmaleimide-sensitive factor attachment protein receptor
(SNARE) proteins form heteromeric complexes that are required for intracellular membrane …

In clathrin-independent endocytosis, Hook1, a microtubule-and cargo-tethering protein,
participates in sorting of cargo proteins such as CD98 (encoded by SLC3A2) and CD147 …

Proteins of the Sec1 family have been shown to interact with target-membrane t-SNAREs
that are homologous to the neuronal protein syntaxin. We demonstrate that yeast Sec1p …