In the inherited degenerative retinal disease of the rd mouse, rod cGMP levels rise above
normal due to depressed cGMP-phosphodiesterase (cGMP-PDE) function a few days before …

The distribution of cyclic GMP, cyclic AMP and related enzymes in the vertebrate retina,
together with factors regulating their levels, are described. Photo-receptor cells in retinas …

Frozen sections of retinas from rabbit (mostly rods), ground squirrel (mostly cones), and
monkey (mixed rods and cones) were freeze dried, and samples from all the discrete layers …

Cyclic nucleotide metabolism in collies afflicted with early onset inherited retinal dysplasia
was investigated with biochemical and histochemical methods. 3′, 5′-Guanosine …

In the inherited retinal degeneration of rd mice, cyclic GMP accumulates in affected rod
photoreceptors prior to their degeneration. A deficiency in the activity of the visual cell …

• Studies on animal models of retinal degeneration have been the focus of many
laboratories during the last decade. With the recent advances in biotechnology that have …

1. Rabbit retinas were isolated and subjected in vitro to shifts between light and darkness in
the presence or absence of four concentrations of the phosphodiesterase inhibitor 3 …

Molecular cloning, sequencing and Northern blot analysis have been performed on the γ-
subunit of cyclic-GMP phosphodiesterase (cGMP-PDE γ) from the retina of mice affected …

Although there is good agreement that light reduces the amount of cyclic GMP (cGMP) in the
retina, the exact time-course of this decrease is not well established. Bullfrog retinal sections …

An abnormality in retinal guanosine 3′, 5′-monophosphate (cyclic GMP) metabolism is
demonstrated in the inherited rod-cone dysplasia of Irish Setter dogs. Affected visual cells …