Photoreceptor metabolism of cGMP and its regulation were characterized in isolated toad
retinas by determining the intensity and time dependence of light-induced changes in the …

Truncated rod photoreceptors containing outer segments with inner segment attachments
were prepared from bovine retinas. In the absence of a high-energy donor, the preparation …

As a result of an early deficiency in cyclic nucleotide phosphodiesterase activity, guanosine
3′, 5′-monophosphate accumulates in retinal photoreceptor cells before they begin to …

Kinetically distinct classes of cyclic AMP (cAMP) and cyclic GMP (cGMP) phosphodiesterase
activities (PDEs) were detected in homogenates of cultured pigment epithelium (PE) from …

Irish setter dogs affected with rod-cone dysplasia 1 have elevated levels of retinal cGMP
resulting from deficient rodqecific cCMP phosphodiesterase (cCMP PDE) activity. We …

Introduction 3. Metabolic and non-metabolic mechanisms to regulate the cGMP
concentration in cells 3.1. Guanylate cyclase (EC 4.6. 1.2) 3.2. Cyclic nucleotide …

Immunochemical, chromatographic, and sodium dodecyl sulfate gel electrophoresis studies
suggest that immunologically related but distinct cyclic GMP phosphodiesterases are …

We cloned the guanylate cyclase activating proteins, GCAP1 and GCAP2, from chicken
retina and examined their expression in normal and predegenerate rd/rd chicken retina …

Purpose: In the rd/rd mouse, the cell death of rod photoreceptors has been correlated to
abnormal levels of the cyclic nucleotide cGMP within photoreceptors. Given that cGMP is …

PURPOSE: Photoexcitation of vertebrate retinal rod photoreceptors stimulates GTP binding
to the transducin alpha subunit. Like other GTP-binding proteins, transducin restores itself to …