Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways
JF Roeth, KL Collins - Microbiology and molecular biology reviews, 2006 - Am Soc Microbiol
The Nef protein of primate lentiviruses is a unique protein that has evolved in several ways
to manipulate the biology of an infected cell to support viral replication, immune evasion …
to manipulate the biology of an infected cell to support viral replication, immune evasion …
HIV‐1 Nef: taking control of protein trafficking
EA Pereira, LLP daSilva - Traffic, 2016 - Wiley Online Library
The Nef protein of the human immunodeficiency virus is a crucial determinant of viral
pathogenesis and disease progression. Nef is abundantly expressed early in infection and …
pathogenesis and disease progression. Nef is abundantly expressed early in infection and …
Human immunodeficiency virus type 1 Nef functions at the level of virus entry by enhancing cytoplasmic delivery of virions
E Schaeffer, R Geleziunas, WC Greene - Journal of virology, 2001 - Am Soc Microbiol
The Nef protein of the type 1 human immunodeficiency virus (HIV-1) plays a key although
poorly understood role in accelerating the progression of clinical disease in vivo. Nef exerts …
poorly understood role in accelerating the progression of clinical disease in vivo. Nef exerts …
How HIV Nef proteins hijack membrane traffic to promote infection
The accessory protein Nef of human immunodeficiency virus (HIV) is a primary determinant
of viral pathogenesis. Nef is abundantly expressed during infection and reroutes a variety of …
of viral pathogenesis. Nef is abundantly expressed during infection and reroutes a variety of …
Virion incorporation of human immunodeficiency virus type 1 Nef is mediated by a bipartite membrane-targeting signal: analysis of its role in enhancement of viral …
R Welker, M Harris, B Cardel… - Journal of virology, 1998 - Am Soc Microbiol
The nef gene of primate immunodeficiency viruses is essential for high-titer virus replication
and AIDS pathogenesis in vivo. In tissue culture, Nef is not required for human …
and AIDS pathogenesis in vivo. In tissue culture, Nef is not required for human …
Implications of Nef: host cell interactions in viral persistence and progression to AIDS
NJ Arhel, F Kirchhoff - HIV Interactions with Host Cell Proteins, 2009 - Springer
Abstract The HIV and SIV Nef accessory proteins are potent enhancers of viral persistence
and accelerate progression to AIDS in HIV-1-infected patients and non-human primate …
and accelerate progression to AIDS in HIV-1-infected patients and non-human primate …
The proteolytic cleavage of human immunodeficiency virus type 1 Nef does not correlate with its ability to stimulate virion infectivity
The Nef protein of human immunodeficiency virus type 1 (HIV-1) promotes virion infectivity
through mechanisms that are yet ill defined. Some Nef is incorporated into particles, where it …
through mechanisms that are yet ill defined. Some Nef is incorporated into particles, where it …
The Nef protein of primate lentiviruses
V Piguet, D Trono - Reviews in medical virology, 1999 - Wiley Online Library
The Nef protein of primate lentiviruses acts as an important virulence factor in vivo both in
monkeys and in humans. Among a human cohort of long‐term non‐progressors, several Nef …
monkeys and in humans. Among a human cohort of long‐term non‐progressors, several Nef …
HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization
AS Baur, ET Sawai, P Dazin, WJ Fantl, C Cheng-Mayer… - Immunity, 1994 - cell.com
Nef of primate lentiviruses is required for viremia and progression to AIDS in monkeys.
Negative, positive, and no effects of Nef have also been reported on viral replication in cells …
Negative, positive, and no effects of Nef have also been reported on viral replication in cells …
Cutting edge: SIV Nef protein utilizes both leucine-and tyrosine-based protein sorting pathways for down-regulation of CD4
PA Bresnahan, W Yonemoto… - The Journal of …, 1999 - journals.aai.org
The Nef protein is unique to primate lentiviruses and is closely linked to accelerated
pathogenesis in both human and monkey hosts. Nef acts to down-regulate CD4 and MHC …
pathogenesis in both human and monkey hosts. Nef acts to down-regulate CD4 and MHC …