Abstract Background" Type II"/Receptor cells express G protein-coupled receptors (GPCRs)
for sweet, umami (T1Rs and mGluRs) or bitter (T2Rs), as well as the proteins for …

Although a role for the gastric and intestinal mucosa in molecular sensing has been known
for decades, the initial molecular recognition events that sense the chemical composition of …

The human T1R taste receptors are family CG‐protein‐coupled receptors (GPCRs) that act
as heterodimers to mediate sweet (hT1R2+ hT1R3) and umami (hT1R1+ hT1R3) taste …

A novel heterotrimeric G-protein γ-subunit has been cloned, and its function has been
confirmed by expression and purification. This γ-subunit is only detected in the olfactory …

We have reported on the partial structures of a multigene family encoding GTP-binding
protein (G protein)-coupled, seven-transmembrane receptors expressed in the tongue (Abe …

Taste receptors for sweet, bitter and umami tastants are G-protein coupled receptors
(GPCRs). While much effort has been devoted to understanding G-protein-receptor …

Gustducin, a Gα subunit expressed in taste cells, is known as a key molecule for sweet,
umami and bitter taste signal transduction. However, previous studies demonstrated that the …

Biochemical studies in vertebrate olfactory tissue indicate that certain odorants stimulate
adenylyl cyclase in a GTP-dependent manner. Additionally, immunochemical and toxin …

To identify genes important for taste receptor cell function, we analyzed the sequences and
expression patterns of clones isolated from a mouse taste receptor cell-enriched cDNA …

The invention provides a series of chimeric 6bG α15 protein variants that couple to certain
GPCRs more efficiently than the native Gα 15 protein. These chimeric G α15 protein variants …