The present studies were undertaken to determine whether neuronal subsets in normal
brains constitutively express functionally competent C5a receptors. In situ hybridization …

In our earlier results, we demonstrated that cells expressing the complement C5aR are
vulnerable since abnormal activation of C5aR caused apoptosis of these cells. In this study …

In this study we explored the potential role of the complement derived anaphylatoxin C5a
and the expression of its receptor in mouse brain. Using in situ hybridization, we found that …

There is now clear evidence that the Complement anaphylatoxin C3a and C5a receptors
(C3aR and C5aR) are expressed in glial cells, notably in astrocytes and microglia. In …

The complement system of innate immunity is emerging as a novel player in
neurodevelopmental processes. The receptor for C3a, C3aR, shares a close evolutionary …

The complement system is thought to be involved in the pathogenesis of numerous
neurological diseases, although its precise role remains controversial. In this study we used …

The C fragment C5a exerts its important physiologic and pathologic effects through
interaction with a specific C5a receptor (C5aR) which is highly expressed on …

Human neuroblastoma TGW cells express a C5a anaphylatoxin receptor-like molecule
termed neuronal C5a receptor. A C5a-receptor fragment peptide (termed PR226-multiple …

C5a receptor (C5aR, CD88) is a receptor originally described on neutrophils and monocyte-
macrophages but recently found on hepatocytes, epithelial cells, endothelial cells, and …

C5a receptors are found in the central nervous system (CNS), on both neurons and glia.
However, the origin of the C5a, which activates these receptors, is unclear. In the present …