CUL4A promotes cell invasion in gastric cancer by activating the NF-κB signaling pathway

Y Gong, XJ Xiang, M Feng, J Chen… - … : Targets and Therapy, 2017 - Taylor & Francis
Cullin 4A (CUL4A) overexpression has been reported to be involved in the carcinogenesis
and progression of many malignant tumors. However, the role of CUL4A in the progression …

CUL4B promotes gastric cancer invasion and metastasis-involvement of upregulation of HER2

M Qi, M Jiao, X Li, J Hu, L Wang, Y Zou, M Zhao… - Oncogene, 2018 - nature.com
Abstract Cullin 4B (CUL4B) is a scaffold protein overexpressed in several solid
malignancies. It is known to silence tumor suppressor through post-transcriptional manner …

[HTML][HTML] Cullin 4A (CUL4A), a direct target of miR-9 and miR-137, promotes gastric cancer proliferation and invasion by regulating the Hippo signaling pathway

J Deng, W Lei, X Xiang, L Zhang, J Lei, Y Gong… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract Although Cullin 4A (CUL4A) is mutated or amplified in several human cancer types,
its role in gastric cancer (GC) and the mechanisms underlying its regulation remain largely …

Upregulation of cullin 4B promotes gastric cancer and predicts poor prognosis

P Wu, H Hu, J Li, W Gong - OncoTargets and therapy, 2020 - Taylor & Francis
Aim Cullin 4B (CUL4B) is a member of the cullin ubiquitin-ligase family, which participates in
proteolysis. Aberrant CUL4B expression has been shown in many malignancies. This study …

Effects of cullin 4B on the proliferation and invasion of human gastric cancer cells

F He, XM Cheng, WL Gu - Molecular medicine reports, 2018 - spandidos-publications.com
The major aim of the present study was to explore the effects of cullin 4B (CUL4B) on the
proliferation and invasion of human gastric cancer cells. Gastric tumor tissues and paired …

[HTML][HTML] Cullin7 promotes epithelial‑mesenchymal transition of esophageal carcinoma via the ERK‑SNAI2 signaling pathway

P Tian, D Liu, L Sun, H Sun - Molecular Medicine …, 2018 - spandidos-publications.com
Abstract Cullin7 (CUL7) is a member of Cullin protein family and exhibits a tumor‑promoting
role in several types of tumors, including breast, liver and ovarian. However, its roles in …

[HTML][HTML] Knockdown of CUL4B inhibits proliferation and promotes apoptosis of colorectal cancer cells through suppressing the Wnt/β-catenin signaling pathway

B Song, H Zhan, Q Bian, J Li - International Journal of Clinical and …, 2015 - ncbi.nlm.nih.gov
Colorectal cancer is one of the leading causes of cancer related deaths worldwide. Cullin 4B
(CUL4B) is over-expressed in diverse cancer types. However, the function and precise …

Cullin-4B promotes cell proliferation and invasion through inactivation of p53 signaling pathway in colorectal cancer

M Zhong, L Zhou, J Zou, Y He, Z Fang… - Pathology-Research and …, 2021 - Elsevier
Abstract Cullin 4B (CUL4B) is a member of the Cullin RING E3 ligase family, which is found
to be overexpressed in multiple cancers, thus facilitating tumorigenesis and progression …

miR‑381 and miR‑489 suppress cell proliferation and invasion by targeting CUL4B via the Wnt/β‑catenin pathway in gastric cancer

Z Fang, M Zhong, Y Wang, X Yuan… - International …, 2019 - spandidos-publications.com
Accumulating evidence has highlighted the critical role of cullin 4B (CUL4B) in driving
tumourigenesis in several malignancies, including gastric cancer (GC); however, the …

[PDF][PDF] CUL4A promotes the invasion of cervical cancer cells by regulating NF-κB signaling pathway.

Q Mei, LJ Ye, H Lin, CY Chen - European Review for Medical & …, 2020 - europeanreview.org
OBJECTIVE: The aim of this study was to investigate the effects of cullin 4A (CUL4A) on
promoting the proliferation and inhibiting the apoptosis of cervical cancer (CC) cells by …