Abstract Cullin 4B (CUL4B), a scaffold protein that assembles CRL4B ubiquitin ligase
complexes, was found to be overexpressed in many types of tumors. However, the …

Previous studies have revealed that CUL4B is overexpressed in various types of cancer and
that its overexpression is related to the progression and metastasis of tumors. However, the …

Abstract Cullin 3 (CUL3), a molecular scaffold of Cullin-RING ubiquitin ligase, plays an
important role in regulating biological processes through modulating the ubiquitylation and …

Abstract Cullin 4B (CUL4B), a scaffold protein of the Cullin4B-RING E3 ligase complex,
functions in proteolysis. The present study aims to investigate its expression pattern and …

The ubiquitin ligase CUL4A has been implicated in tumorigenesis, but its contributions to
progression and metastasis have not been evaluated. Here, we show that CUL4A is …

CUL4A, a member of the CULLIN family, functions as a scaffold protein for an E3 ubiquitin
ligase. It was reported that the CUL4A gene showed amplification in some human primary …

As a core scaffold protein, Cullin 7 (Cul7) forms Skp1-Cullin-F-box (SCF) E3 ubiquitin ligase
complexes with the regulator of cullins-1 (ROC1), S-phase kinase associated protein 1 …

Cullin 4A (Cul4A) is overexpressed in a number of cancers and has been established as an
oncogene. This study aimed to elucidate the role of Cul4A in lung cancer invasion and …

Background and Aims Although it has been indicated that the cytokine interleukin-6 (IL-6)
promotes colorectal cancer (CRC) tumorigenesis in tumor microenvironment, the …

Increasing evidence suggests that CUL4A, a ubiquitin ligase, is involved in the promotion of
cancer malignancy and correlated with worse clinical prognosis in several kinds of human …