Colorectal cancer (CRC) is one of the most common malignant tumors, and its high rates of
recurrence and metastasis are the important causes of treatment failure in CRC. Therefore …

Transcription factors (TFs) and long noncoding RNAs (lncRNAs) contribute to gastric cancer
(GC). However, the roles of TFs and lncRNAs in the invasion and metastasis of GC remain …

MUC1, a membrane tethered mucin glycoprotein, is overexpressed in> 60% of human
pancreatic cancers (PCs), and is associated with poor prognosis and enhanced metastasis …

Abstract Cullin4A (Cul4A) is a scaffold protein that assembles cullin–RING ubiquitin ligase
(E3) complexes and regulates many cellular events, including cell survival, development …

Abstract Cullin 4B (CUL4B) is a component of the Cullin4B-Ring E3 ligase complex
(CRL4B) that functions in proteolysis and is implicated in tumorigenesis. Here, we report that …

Background: Cul-4, a member of the Caenorhabditis elegans “cullin” ubiquitin-ligase gene
family, plays a critical role in regulation of DNA-replication in this nematode. It has been …

Background We aimed to identify novel tumor-promoting drivers highly expressed in gastric
cancer (GC) that contribute to worsened prognosis in affected patients. Methods Genes …

Abstract Downregulation of Mucin 2 (MUC2) expression is associated with early
carcinogenesis events in colon cancer. MUC2 plays a role in the progression of colon …

Given that colorectal cancer stem cells (CCSCs) play key roles in the tumor dormancy,
metastasis, and relapse, targeting CCSCs is a promising strategy in cancer therapy. Here …

Using an expression cloning approach, we identify CUL7, a member of the cullin family, as a
functional inhibitor of Myc-induced apoptosis. Deregulated expression of the Myc oncogene …