Although several molecular targeted therapy and immunotherapy have been developed,
cutaneous melanoma prognosis is still not satisfying. Cul4b promotes the progression of …

Infection with Helicobacter pylori is important in the development and progression of gastric
cancer. However, the mechanisms that regulate this activation in gastric tumors remain …

This study was designed to explore the role of Cullin1 (Cul1) in the pathogenesis of human
glioma and to investigate the role of Cul1 in the growth, migration and invasion of glioma …

Abstract Claudin6 (CLDN6), a member of the tight junction family, is a molecule involved in
intercellular adhesion, acting as a physical barrier that prevents solutes and water from …

Deregulated expressions of mucins have been found in various malignancies and play a
pivotal role in carcinogenesis. MUC5AC, as a secreted mucin, is reported to be aberrantly …

Background Differential expression of mucins has been associated with several cancers
including colorectal cancer (CRC). In normal physiological conditions, secretory mucin …

Mucins play a key role in tumorigenesis. MUC15 is a membrane-bound mucin and the
MUC15 messenger RNA (mRNA) has been detected in various organs. However, its role in …

Purpose Growing evidence indicates that aberrant expression of microRNAs contributes to
tumor development. However, the biological role of microRNA-4490 (miR-4490) in gastric …

Osteosarcoma (OS) is the most common bone malignancy in the pediatric population, and it
comprises about 3% of all pediatric tumors. Aberrant expression of the Cullin 4A (CUL4A) is …

Background There is no reliable marker available for early detection, diagnostic confirmation
or disease prognosis of osteosarcoma. Cullin-1 (CUL1) is a newly reported tumor-related …