The functional analysis of Cullin 7 E3 ubiquitin ligases in cancer

L Shi, D Du, Y Peng, J Liu, J Long - Oncogenesis, 2020 - nature.com
Cullin (CUL) proteins have critical roles in development and cancer, however few studies on
CUL7 have been reported due to its characteristic molecular structure. CUL7 forms a …

Analysis of CUL-5 expression in breast epithelial cells, breast cancer cell lines, normal tissues and tumor tissues

MJ Fay, KA Longo, GA Karathanasis, DM Shope… - Molecular Cancer, 2003 - Springer
Background The chromosomal location of CUL-5 (11q 22-23) is associated with LOH in
breast cancer, suggesting that CUL-5 may be a tumor suppressor. The purpose of this …

MUC3A promotes the progression of colorectal cancer through the PI3K/Akt/mTOR pathway

W Su, B Feng, L Hu, X Guo, M Yu - BMC cancer, 2022 - Springer
Abstract Mucin 3A (MUC3A) is overexpressed in colorectal cancer (CRC) and associated
with poor prognosis, but the related mechanism remains unclear. Our study found that …

CCL18 promotes the invasion and migration of gastric cancer cells via ERK1/2/NF-κB signaling pathway

X Hou, Y Zhang, H Qiao - Tumor Biology, 2016 - Springer
CCL18 is a member of CCL chemokines and is frequently overexpressed in cancer.
Elevated CCL18 expression has been reported to be associated with poor prognosis of …

Mining the role of RECQL5 in gastric cancer and seeking potential regulatory network by bioinformatics analysis

Y Lin, H Chen, X Wang, J Xiang, H Wang… - … and Molecular Pathology, 2020 - Elsevier
Abstract Aim The role of RecQ protein-like 5 (RECQL5) in gastric carcinoma (GC) is still
unclear. Here, we investigated the role of RECQL5 in human GC and its potential regulatory …

CUL4B activates Wnt/β‐catenin signalling in hepatocellular carcinoma by repressing Wnt antagonists

J Yuan, B Han, H Hu, Y Qian, Z Liu, Z Wei… - The Journal of …, 2015 - Wiley Online Library
Activation of Wnt/β‐catenin signalling is frequently observed in many types of cancer
including hepatocellular carcinoma (HCC). We recently reported that cullin 4B (CUL4B), a …

OTUD7B deubiquitinates and stabilizes YAP1 to upregulate NUAK2 expression, thus accelerating gastric cancer procession

Z Guo, L Guo - Digestive and Liver Disease, 2024 - Elsevier
Background Gastric cancer (GC) is one of the most common malignancies worldwide.
Ovarian tumor protein superfamily serves a crucial role in tumor growth progression, among …

Cancer-associated fibroblasts-derived VCAM1 induced by H. pylori infection facilitates tumor invasion in gastric cancer

J Shen, J Zhai, Q You, G Zhang, M He, X Yao, L Shen - Oncogene, 2020 - nature.com
Cancer-associated fibroblasts (CAFs) play a major role in the progression of stomach
cancer, but the related mechanisms are not fully understood. H. pylori infection is recognized …

MUC1 protein expression in tumor cells regulates transcription of proinflammatory cytokines by forming a complex with nuclear factor-κB p65 and binding to cytokine …

S Cascio, L Zhang, OJ Finn - Journal of Biological Chemistry, 2011 - ASBMB
MUC1 is a transmembrane glycoprotein abnormally expressed in all stages of development
of human adenocarcinomas. Overexpression and hypoglycosylation of MUC1 in cancer …

NUSAP1 promotes gastric cancer tumorigenesis and progression by stabilizing the YAP1 protein

H Guo, J Zou, L Zhou, M Zhong, Y He, S Huang… - Frontiers in …, 2021 - frontiersin.org
The Yes-associated protein (YAP1) is a main effector of the canonical Hippo pathway, which
contributes greatly to tumor initiation, progression, and metastasis in multiple cancers …