The mitochondrion is a dynamic membranous network whose morphology is conditioned by
the equilibrium between ongoing fusion and fission of mitochondrial membranes. In the …

Mitochondrial morphology depends on balanced fusion and fission events. A central
component of the mitochondrial fusion apparatus is the conserved GTPase Fzo1 in the outer …

Mitochondrial fusion and fission play important roles for mitochondrial morphology and
function. We identified Mdm30 as a novel component required for maintenance of fusion …

The ability of cells to respire requires that mitochondria undergo fusion and fission of their
outer and inner membranes. The means by which levels of fusion 'machinery'components …

Mitofusin proteins 1 and 2 (Mfn1 and Mfn2, respectively) of the mammalian mitochondrial
outer membrane are homologues of Drosophila FZO and yeast Fzo1, and both are essential …

Mitochondria are dynamic organelles that undergo frequent fission and fusion or branching.
Although these morphologic changes are considered crucial for cellular functions, the …

Mitofusins, conserved dynamin-related GTPases in the mitochondrial outer membrane,
mediate the fusion of mitochondria. Here, we demonstrate that the activity of the mitofusin …

The mammalian homologues of yeast and Drosophila Fzo, mitofusin (Mfn) 1 and 2, are both
essential for mitochondrial fusion and maintenance of mitochondrial morphology. Though …

Dynamin-related GTPase proteins (DRPs) are main players in membrane remodelling.
Conserved DRPs called mitofusins (Mfn1/Mfn2/Fzo1) mediate the fusion of mitochondrial …

Mitofusins are conserved GTPases essential for the fusion of mitochondria. These
mitochondrial outer membrane proteins contain a GTPase domain and two or three regions …