Despite the knowledge of many of the genetic alterations present in osteosarcoma, its
complexity precludes placing its biology into a simple conceptual framework. In contrast to …

Osteosarcoma is the most common primary malignancy of bone in children and young
adults. This tumor has a very heterogeneous genetic profile and lacks any consistent …

Clinical outcomes and treatment modalities for osteosarcoma, the most common primary
cancer of bone, have changed very little over the past 30 years. The peak incidence of …

Osteosarcoma is the most common primary malignant bone tumor in children and young
adults. The standard-of-care curative treatment for osteosarcoma utilizes doxorubicin …

Osteosarcoma is the most common nonhematologic malignancy of bone in children and
adults. The peak incidence occurs in the second decade of life, with a smaller peak after age …

Osteosarcoma is a relatively uncommon malignancy with about 1000 new cases diagnosed
each year in the United States. It is, however, among the most common nonhematologic …

Osteosarcoma is the most common primary malignant bone tumor in children and
adolescents. Despite significant clinical improvements over the past several decades …

In this Update, the cytogenetic and molecular genetic findings in osteosarcoma (OS) and
some related tumors published since our book appeared in 1994 [1] will be presented and …

Osteosarcoma is the most common primary malignancy of bone, typically presenting in the
first or second decade of life. Unfortunately, clinical outcomes for osteosarcoma patients …

Osteosarcoma is the most common primary malignancy of bone. It arises in bone during
periods of rapid growth and primarily affects adolescents and young adults. The 5‐year …