In mouse, the oocyte-to-embryo transition entails converting a highly differentiated oocyte to
totipotent blastomeres. This transition is driven by degradation of maternal mRNAs, which …

Post-transcriptional mechanisms play a central role in regulating gene expression during
oogenesis and early embryogenesis. Growing oocytes accumulate an enormous quantity of …

Vertebrate oocytes face a particular challenge concerning the regulation of gene expression
during meiotic maturation. Global transcription becomes quiescent in fully grown oocytes …

The oocyte‐to‐embryo transition (OET) is thought to be mainly driven by post‐transcriptional
gene regulation. However, expression of both RNA s and proteins during the OET has not …

Degradation of maternal mRNA is thought to be essential to undergo the maternal-to-
embryonic transition. Messenger RNA is extremely stable during oocyte growth in mouse …

The oocyte-to-zygote transition entails transforming a highly differentiated oocyte into
totipotent blastomeres and represents one of the earliest obstacles that must be successfully …

Epigenetic reprogramming of the parental genomes upon fertilization is required for proper
embryonic development. It has long been appreciated that asymmetric distribution of histone …

Following fertilization, embryos develop for a substantial amount of time with a
transcriptionally silent genome. Thus, early development is maternally programmed, as it …

In mammals, maternal-to-zygotic transition (MZT), or oocyte-to-embryo transition, begins with
oocyte meiotic resumption due to the sequential translational activation and destabilization …

The oocyte-to-embryo transition (OET) is regulated by maternal products stored in the oocyte
cytoplasm, independent of transcription. How maternal products are precisely remodeled to …